Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 383723..384356 Replicon chromosome
Accession NZ_AP024874
Organism Vibrio gazogenes strain ATCC 29988

Toxin (Protein)


Gene name higB Uniprot ID A0A1M4TW45
Locus tag OCU45_RS17345 Protein ID WP_072954888.1
Coordinates 383723..384055 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1M4TVZ1
Locus tag OCU45_RS17350 Protein ID WP_072954890.1
Coordinates 384042..384356 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU45_RS17325 379794..380549 - 756 WP_072954879.1 DUF3307 domain-containing protein -
OCU45_RS17330 380542..381192 - 651 WP_072954881.1 hypothetical protein -
OCU45_RS17335 381395..382081 - 687 WP_072954883.1 NYN domain-containing protein -
OCU45_RS17340 382484..383581 + 1098 WP_072954886.1 phosphotransferase -
OCU45_RS17345 383723..384055 + 333 WP_072954888.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OCU45_RS17350 384042..384356 + 315 WP_072954890.1 DNA-binding transcriptional regulator Antitoxin
OCU45_RS17355 384448..385344 - 897 WP_072954893.1 LysR family transcriptional regulator -
OCU45_RS17360 385449..386330 + 882 WP_072954895.1 N-carbamoylputrescine amidase -
OCU45_RS17365 386326..387726 + 1401 WP_072954898.1 APC family permease -
OCU45_RS17370 387723..388811 + 1089 WP_072954901.1 agmatine deiminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(44-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-101)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12951.77 Da        Isoelectric Point: 8.7159

>T39786 WP_072954888.1 NZ_AP024874:383723-384055 [Vibrio gazogenes]
MKSVFVESTIFEKYREDYLSDEEYRLFQVELMSNPKYGDVIQGTGGLRKIRVASKGKGKRGGSRVIYYYLDEHHRFYLLT
IYAKNEMADLTADQKKQLKAFMEAWCNEQS

Download         Length: 333 bp

>T39786 NZ_AP024874:383723-384055 [Vibrio gazogenes]
ATGAAAAGTGTATTTGTCGAATCAACCATATTTGAAAAGTATCGTGAGGATTATCTAAGTGACGAAGAGTATCGGCTTTT
TCAAGTCGAGCTAATGTCTAATCCAAAGTATGGTGATGTAATCCAAGGTACAGGAGGTCTGCGGAAAATACGAGTAGCAA
GTAAGGGAAAAGGGAAGCGTGGTGGTTCACGCGTTATCTATTACTATCTCGATGAACATCATCGATTTTACTTGCTGACC
ATTTATGCGAAGAATGAAATGGCCGATTTAACCGCAGATCAAAAGAAACAGCTAAAAGCTTTTATGGAGGCATGGTGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11764.28 Da        Isoelectric Point: 6.9907

>AT39786 WP_072954890.1 NZ_AP024874:384042-384356 [Vibrio gazogenes]
MSNRDLFGELSSALVEAKEHSEGKLTLKTHRVGDVGERHITPDEIVHIREQFNMSRGVFARLLHTSSRTLENWEQGRSAP
NGQAVTLLKLVQRYPETLSQIAEL

Download         Length: 315 bp

>AT39786 NZ_AP024874:384042-384356 [Vibrio gazogenes]
ATGAGCAATCGTGATTTATTTGGAGAATTAAGTTCAGCACTTGTTGAAGCTAAGGAGCACTCAGAAGGTAAGTTGACGCT
GAAAACCCATCGGGTTGGTGATGTGGGTGAACGTCATATTACACCTGATGAAATTGTTCATATTCGAGAGCAGTTCAATA
TGTCACGGGGTGTTTTTGCTCGTTTACTTCATACCTCATCACGTACACTGGAAAACTGGGAACAAGGGCGTAGTGCACCG
AATGGGCAGGCGGTCACGCTTCTAAAATTAGTACAACGTTATCCGGAAACATTGTCACAGATAGCTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M4TW45

Antitoxin

Source ID Structure
AlphaFold DB A0A1M4TVZ1

References