Detailed information of TA system TA039779

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-MqsA
• Location: 116597..117230
• Replicon: chromosome
• Accession: NZ_AP024865
• Organism: Vibrio breoganii strain CAIM 1829

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A193KIJ2
• Locus tag: OCU35_RS13795
• Protein ID: WP_017028234.1
• Coordinates: 116898..117230 (-)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: OCU35_RS13790
• Protein ID: WP_017028235.1
• Coordinates: 116597..116911 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCU35_RS13770	112161..113036	-	876	WP_102543208.1	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	-
OCU35_RS13775	113432..113662	+	231	WP_026012860.1	DUF3622 domain-containing protein	-
OCU35_RS13780	113883..115127	+	1245	WP_137000939.1	NADH:flavin oxidoreductase/NADH oxidase family protein	-
OCU35_RS13785	115392..116435	+	1044	WP_065598282.1	DUF1254 domain-containing protein	-
OCU35_RS13790	116597..116911	-	315	WP_017028235.1	DNA-binding transcriptional regulator	Antitoxin
OCU35_RS13795	116898..117230	-	333	WP_017028234.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCU35_RS13800	117613..118497	-	885	WP_261826293.1	LysR substrate-binding domain-containing protein	-
OCU35_RS13805	118699..120159	+	1461	WP_017028232.1	N-acetylglucosamine-specific PTS transporter subunit IIBC	-
OCU35_RS13810	120396..121325	-	930	WP_102360358.1	NADP-dependent oxidoreductase	-
OCU35_RS13815	121398..121820	-	423	WP_017028230.1	organic hydroperoxide resistance protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (4-104)

Antitoxin

• Antitoxin MqsA/HigA-2 (18-101)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12948.80 Da
• Isoelectric Point: 10.1187

>T39779 WP_017028234.1 NZ_AP024865:c117230-116898 [Vibrio breoganii]
MKSIFVESTIFEKYRNEYLSDDEFRLFQAELMSNPKQGDVIQGTGGLRKIRVASKGKGKRGGSRVIYYFLDERRRFYLLT
IYGKNEMSDLTADQKKQLKAFMEAWRNEQS

Nucleotide

• Length: 333 bp

>T39779 NZ_AP024865:c117230-116898 [Vibrio breoganii]
ATGAAAAGTATATTTGTCGAATCAACCATATTTGAAAAGTATCGCAATGAATATCTAAGTGATGATGAGTTTAGGCTTTT
TCAAGCTGAGTTAATGTCTAACCCAAAACAAGGGGACGTGATTCAGGGTACAGGTGGTTTGCGAAAGATTCGAGTTGCAA
GTAAAGGTAAGGGCAAGCGTGGCGGGTCTCGGGTTATCTATTACTTCCTCGATGAAAGACGTCGTTTCTACTTACTGACA
ATTTATGGCAAGAATGAAATGTCCGATTTAACCGCAGACCAAAAGAAACAACTAAAGGCTTTTATGGAGGCGTGGCGTAA
TGAGCAATCGTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11713.14 Da
• Isoelectric Point: 6.2155

>AT39779 WP_017028235.1 NZ_AP024865:c116911-116597 [Vibrio breoganii]
MSNRDLFAELSSALVEAQEHSEGKLTLKTHHVNNISELDISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSAP
NGQAVTLLKLVQRHPETLSHIAEL

Nucleotide

• Length: 315 bp

>AT39779 NZ_AP024865:c116911-116597 [Vibrio breoganii]
ATGAGCAATCGTGATCTATTTGCAGAGTTAAGTTCAGCTCTTGTTGAGGCTCAAGAGCATTCCGAGGGTAAACTAACCCT
TAAAACTCATCATGTTAACAATATCAGTGAGCTAGATATTTCACCTGATGAAATCGTGAGTATTCGTGAGCAGTTTAATA
TGTCGCGTGGTGTGTTTGCGCGTTTGCTGCATACATCATCTCGTACACTAGAAAACTGGGAACAAGGGCGTAGCGCACCA
AATGGACAAGCGGTAACCCTTCTAAAATTGGTTCAGCGTCATCCTGAAACTCTGTCTCATATCGCTGAACTATAA

Structures

Toxin

• AlphaFold DB: A0A193KIJ2