Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2720150..2720745 Replicon chromosome
Accession NZ_AP024861
Organism Vibrio aerogenes strain LMG 19650

Toxin (Protein)


Gene name higB Uniprot ID A0A1M5Y3J7
Locus tag OCV29_RS12065 Protein ID WP_073603208.1
Coordinates 2720425..2720745 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1M5Y3Y4
Locus tag OCV29_RS12060 Protein ID WP_073603209.1
Coordinates 2720150..2720428 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCV29_RS12040 2715625..2716578 + 954 WP_073603212.1 transposase -
OCV29_RS12045 2716813..2717982 - 1170 WP_073603211.1 hypothetical protein -
OCV29_RS12050 2718035..2718478 - 444 WP_073603210.1 DUF4157 domain-containing protein -
OCV29_RS12055 2718509..2719957 - 1449 WP_084193283.1 ATP-binding protein -
OCV29_RS12060 2720150..2720428 - 279 WP_073603209.1 helix-turn-helix transcriptional regulator Antitoxin
OCV29_RS12065 2720425..2720745 - 321 WP_073603208.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OCV29_RS12070 2720995..2722812 - 1818 WP_073603207.1 sigma-54-dependent Fis family transcriptional regulator -
OCV29_RS12075 2723104..2724624 + 1521 WP_073603206.1 aldehyde dehydrogenase family protein -
OCV29_RS12080 2724960..2725433 - 474 WP_073603205.1 peroxiredoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-87)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12256.43 Da        Isoelectric Point: 10.0310

>T39774 WP_073603208.1 NZ_AP024861:c2720745-2720425 [Vibrio aerogenes]
MSWNIEFYDGVEETILGMPPKLQARIIRLLELIEQYGAHLGEPHTKAMGNGLFEIRAKAREGIGRVLFCYLRGTNIIVLH
TFVKKSQKVPKKEIQLAYQRMREVTQ

Download         Length: 321 bp

>T39774 NZ_AP024861:c2720745-2720425 [Vibrio aerogenes]
ATGAGTTGGAATATTGAGTTTTATGATGGCGTTGAGGAAACCATTCTGGGGATGCCACCAAAGCTTCAGGCCAGAATAAT
CAGGTTACTGGAGTTGATTGAGCAATATGGTGCACATCTTGGAGAGCCTCATACTAAAGCTATGGGTAATGGGTTGTTTG
AAATTCGTGCAAAAGCCAGAGAAGGAATTGGGCGTGTACTGTTTTGCTATCTGAGGGGAACCAATATCATTGTGCTTCAT
ACTTTTGTTAAGAAAAGTCAAAAAGTCCCCAAAAAAGAAATTCAACTGGCTTATCAACGGATGAGAGAGGTAACCCAATG
A

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10266.03 Da        Isoelectric Point: 10.0177

>AT39774 WP_073603209.1 NZ_AP024861:c2720428-2720150 [Vibrio aerogenes]
MNPLRSLKNKALSDPAVKAEYDALAPEFRLIKTLLAMRETAGLTQLQVAERMGTKEANISRLEKGNGNPTLKTLAKYAHA
CGCELEFMFRRL

Download         Length: 279 bp

>AT39774 NZ_AP024861:c2720428-2720150 [Vibrio aerogenes]
ATGAACCCGTTACGGTCGTTAAAAAACAAAGCGCTTTCAGATCCGGCGGTGAAGGCTGAATATGATGCTTTAGCGCCTGA
ATTCAGATTAATCAAAACTCTGCTTGCCATGCGTGAAACCGCTGGTCTGACTCAATTGCAGGTTGCAGAACGGATGGGTA
CGAAAGAAGCAAATATATCAAGGCTTGAGAAAGGTAATGGCAACCCGACCCTGAAGACGCTGGCGAAATACGCTCATGCC
TGTGGATGTGAGCTGGAGTTTATGTTCAGGCGTCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M5Y3J7

Antitoxin

Source ID Structure
AlphaFold DB A0A1M5Y3Y4

References