Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1140600..1141245 Replicon chromosome
Accession NZ_AP024861
Organism Vibrio aerogenes strain LMG 19650

Toxin (Protein)


Gene name higB Uniprot ID A0A1M5ZSD7
Locus tag OCV29_RS05255 Protein ID WP_073604756.1
Coordinates 1140600..1140959 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1M5ZS36
Locus tag OCV29_RS05260 Protein ID WP_073604757.1
Coordinates 1140940..1141245 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCV29_RS05220 1135617..1136333 + 717 WP_073604731.1 dienelactone hydrolase family protein -
OCV29_RS05225 1136436..1136744 - 309 WP_073604732.1 hypothetical protein -
OCV29_RS05230 1137153..1137410 - 258 WP_073604751.1 type II toxin-antitoxin system ParD family antitoxin -
OCV29_RS05235 1137836..1138255 - 420 WP_073604752.1 type II toxin-antitoxin system MqsA family antitoxin -
OCV29_RS05240 1138266..1138694 - 429 WP_073604753.1 hypothetical protein -
OCV29_RS05245 1139087..1139785 - 699 WP_245796930.1 winged helix-turn-helix domain-containing protein -
OCV29_RS05250 1139829..1140152 - 324 WP_073604755.1 antibiotic biosynthesis monooxygenase -
OCV29_RS05255 1140600..1140959 + 360 WP_073604756.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OCV29_RS05260 1140940..1141245 + 306 WP_073604757.1 XRE family transcriptional regulator Antitoxin
OCV29_RS05265 1141871..1142773 - 903 WP_073604759.1 HEPN domain-containing protein -
OCV29_RS05270 1143075..1144652 + 1578 WP_073604760.1 class I SAM-dependent DNA methyltransferase -
OCV29_RS05275 1144636..1145823 + 1188 WP_073604761.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(19-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13898.15 Da        Isoelectric Point: 9.9270

>T39771 WP_073604756.1 NZ_AP024861:1140600-1140959 [Vibrio aerogenes]
MWNVVLRPMFLAWFQSLSSEDKVNVRASLELLKEKGPNLPRPHVDTLSNTKLKKLKELRVQSHGKPLRVFFAFDPERRCV
VLCAGDKTGDKRFYKKMIPIAEDEFKEHLQEIDNEKSNT

Download         Length: 360 bp

>T39771 NZ_AP024861:1140600-1140959 [Vibrio aerogenes]
ATGTGGAACGTCGTATTAAGACCTATGTTTTTGGCGTGGTTTCAATCACTGTCCAGCGAGGATAAAGTAAACGTCAGGGC
TTCGCTGGAACTCTTAAAAGAAAAGGGGCCGAATTTACCACGCCCTCATGTTGACACACTCAGCAATACAAAACTTAAGA
AGCTTAAAGAGCTGAGAGTACAAAGTCATGGTAAACCTCTTCGGGTGTTTTTTGCGTTCGATCCCGAGCGTCGGTGCGTC
GTGCTTTGCGCAGGGGACAAAACAGGGGATAAGAGGTTTTATAAAAAGATGATTCCGATAGCAGAAGATGAGTTTAAGGA
ACATCTACAGGAGATAGACAATGAAAAGTCAAACACTTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11210.98 Da        Isoelectric Point: 5.1957

>AT39771 WP_073604757.1 NZ_AP024861:1140940-1141245 [Vibrio aerogenes]
MKSQTLDALDALMTDDELAQAKAKAESMLFELNLAEFRRIVQKSQTEVADIMGVKQPTVANLEKNGKDVKLLSLKRYIEA
LGGKLRLDVELPDGTHRGLDI

Download         Length: 306 bp

>AT39771 NZ_AP024861:1140940-1141245 [Vibrio aerogenes]
ATGAAAAGTCAAACACTTGATGCGTTAGACGCTTTGATGACAGATGATGAGCTGGCTCAGGCAAAAGCGAAAGCTGAATC
AATGCTTTTCGAGTTAAATTTGGCTGAGTTTCGCCGTATTGTCCAGAAATCGCAGACAGAAGTTGCTGATATTATGGGGG
TTAAACAGCCTACAGTGGCTAACCTTGAAAAGAATGGCAAAGATGTCAAATTACTGTCCTTGAAACGTTATATTGAAGCA
TTGGGTGGCAAATTAAGACTGGATGTTGAATTGCCTGATGGTACGCATCGGGGCTTAGATATTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M5ZSD7

Antitoxin

Source ID Structure
AlphaFold DB A0A1M5ZS36

References