Detailed information of TA system TA039761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 4375729..4376381
• Replicon: chromosome
• Accession: NZ_AP024847
• Organism: Serratia marcescens strain 2020-O-9

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LDN81_RS21145
• Protein ID: WP_041036518.1
• Coordinates: 4375729..4376073 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A086GAN0
• Locus tag: LDN81_RS21150
• Protein ID: WP_004931828.1
• Coordinates: 4376079..4376381 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDN81_RS21135 (SMGES_41880)	4372072..4374330	-	2259	WP_041036515.1	molybdopterin guanine dinucleotide-containing S/N-oxide reductase	-
LDN81_RS21140 (SMGES_41890)	4374551..4375570	+	1020	WP_033649496.1	HTH-type transcriptional regulator GalR	-
LDN81_RS21145 (SMGES_41900)	4375729..4376073	+	345	WP_041036518.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LDN81_RS21150 (SMGES_41910)	4376079..4376381	+	303	WP_004931828.1	XRE family transcriptional regulator	Antitoxin
LDN81_RS21155 (SMGES_41920)	4376409..4377671	-	1263	WP_033649495.1	diaminopimelate decarboxylase	-
LDN81_RS21160 (SMGES_41930)	4377805..4378728	+	924	WP_060428843.1	LysR family transcriptional regulator	-
LDN81_RS21165 (SMGES_41940)	4378756..4379664	-	909	WP_041036522.1	LysR family transcriptional regulator	-
LDN81_RS21170 (SMGES_41950)	4379773..4380657	+	885	WP_041036524.1	MBL fold metallo-hydrolase	-
LDN81_RS21175 (SMGES_41960)	4380726..4381373	+	648	WP_039567349.1	DsbA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-85)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13425.48 Da
• Isoelectric Point: 10.4277

>T39761 WP_041036518.1 NZ_AP024847:4375729-4376073 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIYKLQTFGPQLTRPHADTLYFSDAVRQLKELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Nucleotide

• Length: 345 bp

>T39761 NZ_AP024847:4375729-4376073 [Serratia marcescens]
ATGTGGCAAGTGGTGACCGTCGAACGGTTCGACGACTGGTTTTTAGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTACAAATTGCAGACGTTCGGCCCGCAGTTGACGCGGCCGCATGCCGATACGCTGTATTTTTCCGACGCGGTCC
GGCAGTTGAAGGAGCTGCGCGTTCAACACCGCGGGCGCCCTTTCAGGGTGTTTTTCGCCTTTGACCCACAGCGGCAAGCG
GTATTGCTGTGCGGTGGCGATAAAACCGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11080.97 Da
• Isoelectric Point: 10.1998

>AT39761 WP_004931828.1 NZ_AP024847:4376079-4376381 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Nucleotide

• Length: 303 bp

>AT39761 NZ_AP024847:4376079-4376381 [Serratia marcescens]
ATGGCCAAACCTTTATCCCAACTGATCGATAAACTCGATCCCGCCGTCGTTGCCGCCGCCAGGCAAAAAGCGGACCAGGA
AATTTTCGAGCTGCGGCTGGCGATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATCAAACTGTCATCGCTCAAACGCTATATCGAGGCCATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAGCACCGCCGCATGACGCTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A086GAN0