Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3522584..3523244 Replicon chromosome
Accession NZ_AP024847
Organism Serratia marcescens strain 2020-O-9

Toxin (Protein)


Gene name higB Uniprot ID A0A7D6BYZ0
Locus tag LDN81_RS17145 Protein ID WP_041035904.1
Coordinates 3522891..3523244 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2V4GQ69
Locus tag LDN81_RS17140 Protein ID WP_033635213.1
Coordinates 3522584..3522886 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDN81_RS17120 (SMGES_33900) 3518206..3519120 - 915 WP_004928592.1 branched-chain amino acid ABC transporter permease -
LDN81_RS17125 (SMGES_33910) 3519246..3520364 - 1119 WP_033647954.1 branched-chain amino acid ABC transporter substrate-binding protein -
LDN81_RS17135 (SMGES_33920) 3520968..3522176 - 1209 WP_041035902.1 aldose 1-epimerase family protein -
LDN81_RS17140 (SMGES_33930) 3522584..3522886 - 303 WP_033635213.1 XRE family transcriptional regulator Antitoxin
LDN81_RS17145 (SMGES_33940) 3522891..3523244 - 354 WP_041035904.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDN81_RS17150 (SMGES_33950) 3523684..3524979 + 1296 WP_041035906.1 MFS transporter -
LDN81_RS17155 (SMGES_33960) 3525007..3525813 + 807 WP_041035908.1 substrate-binding domain-containing protein -
LDN81_RS17160 (SMGES_33970) 3525788..3526687 - 900 WP_039565149.1 LysR family transcriptional regulator -
LDN81_RS17165 (SMGES_33980) 3526780..3527145 - 366 WP_033635218.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13446.27 Da        Isoelectric Point: 8.9000

>T39759 WP_041035904.1 NZ_AP024847:c3523244-3522891 [Serratia marcescens]
VWEIKTTDAFDNWFSSLHDADRAGVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMIQAADREFTNWLNTLNEKE

Download         Length: 354 bp

>T39759 NZ_AP024847:c3523244-3522891 [Serratia marcescens]
GTGTGGGAAATTAAAACAACGGATGCGTTTGATAACTGGTTTAGCTCACTCCACGATGCCGATCGGGCTGGCGTGCTTGC
CGCATTGATGGTCCTGCGGGAAAAGGGGCCGGGGCTGCCCAGACCCTATGCCGATACGGTTAAAGGTTCGCGTTACAGCA
ATATGAAAGAGCTGCGCATTCAGAGCCGTGGCGAACCGTTGCGGGCATTCTTCGCCTTCGATCCGTACCGTATCGGCATT
GTGCTTTGCGCGGGCAATAAAGCCGGTAATGAAAAACGTTTTTACGATCGGATGATTCAGGCTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11079.94 Da        Isoelectric Point: 6.4738

>AT39759 WP_033635213.1 NZ_AP024847:c3522886-3522584 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT39759 NZ_AP024847:c3522886-3522584 [Serratia marcescens]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAAGCGCTGGCGGCTGACAT
CATGCTGAACATCCACCTTGCCGAGCTGCGCGAGAAGGTGCAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGTATCC
GGCAACCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTCAAACGCTATGTTGAGGCGGCC
GGCGGCAAGCTGCGCCTGGATGTTGAACTGCCAGACGGCTCTCACTACGAATTTGTGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6BYZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A2V4GQ69

References