Detailed information of TA system TA039729

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2099821..2100472
• Replicon: chromosome
• Accession: NZ_AP024802
• Organism: Acinetobacter baumannii strain OCU Ac18

Toxin (Protein)

• Gene name: higB
• Uniprot ID: S3SZA7
• Locus tag: OCUAc18_RS10285
• Protein ID: WP_000269903.1
• Coordinates: 2100116..2100472 (-)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: OCUAc18_RS10280
• Protein ID: WP_001140619.1
• Coordinates: 2099821..2100123 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCUAc18_RS10245 (OCUAc18_20010)	2094944..2095180	-	237	WP_000094891.1	helix-turn-helix transcriptional regulator	-
OCUAc18_RS10250 (OCUAc18_20020)	2095345..2095696	-	352	Protein_2014	IS630 transposase-related protein	-
OCUAc18_RS19915 (OCUAc18_20030)	2095839..2096087	+	249	WP_002084120.1	diguanylate cyclase	-
OCUAc18_RS19920	2096099..2096539	+	441	Protein_2016	phosphate-starvation-inducible PsiE family protein	-
OCUAc18_RS19925	2096531..2096945	+	415	Protein_2017	M48 family metalloprotease	-
OCUAc18_RS10270 (OCUAc18_20050)	2096965..2098116	+	1152	WP_000221973.1	trypsin-like peptidase domain-containing protein	-
OCUAc18_RS10275 (OCUAc18_20060)	2098698..2099630	-	933	WP_004739252.1	IS5-like element ISAba13 family transposase	-
OCUAc18_RS10280 (OCUAc18_20080)	2099821..2100123	-	303	WP_001140619.1	XRE family transcriptional regulator	Antitoxin
OCUAc18_RS10285 (OCUAc18_20090)	2100116..2100472	-	357	WP_000269903.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCUAc18_RS10290 (OCUAc18_20100)	2101022..2102347	-	1326	Protein_2022	ISNCY family transposase	-
OCUAc18_RS10295 (OCUAc18_20110)	2102904..2105165	+	2262	WP_221255290.1	excinuclease ABC subunit UvrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2049129..2102023	52894
	-	inside	IScluster/Tn	-	-	2098698..2102023	3325

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (13-89)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13486.45 Da
• Isoelectric Point: 7.1645

>T39729 WP_000269903.1 NZ_AP024802:c2100472-2100116 [Acinetobacter baumannii]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG

Nucleotide

• Length: 357 bp

>T39729 NZ_AP024802:c2100472-2100116 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11206.01 Da
• Isoelectric Point: 6.7282

>AT39729 WP_001140619.1 NZ_AP024802:c2100123-2099821 [Acinetobacter baumannii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Nucleotide

• Length: 303 bp

>AT39729 NZ_AP024802:c2100123-2099821 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA

Structures

Toxin

• AlphaFold DB: A0A836MG83