Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 22309..22960 | Replicon | plasmid pOCUAc17-1 |
| Accession | NZ_AP024799 | ||
| Organism | Acinetobacter pittii strain OCU Ac17 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | S3SZA7 |
| Locus tag | OCUAc17_RS19245 | Protein ID | WP_000269903.1 |
| Coordinates | 22604..22960 (-) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | OCUAc17_RS19240 | Protein ID | WP_001140619.1 |
| Coordinates | 22309..22611 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OCUAc17_RS19195 (OCUAc17_37450) | 17817..18374 | + | 558 | Protein_18 | hypothetical protein | - |
| OCUAc17_RS19200 (OCUAc17_37460) | 18398..18622 | + | 225 | WP_016653391.1 | hypothetical protein | - |
| OCUAc17_RS19205 (OCUAc17_37480) | 18906..19193 | - | 288 | WP_001258992.1 | helix-turn-helix transcriptional regulator | - |
| OCUAc17_RS19210 (OCUAc17_37490) | 19180..19347 | - | 168 | WP_002072926.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| OCUAc17_RS19215 (OCUAc17_37500) | 19645..19965 | - | 321 | WP_002123990.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| OCUAc17_RS19220 | 20333..20539 | + | 207 | WP_242439879.1 | AAA family ATPase | - |
| OCUAc17_RS19225 | 20467..21012 | + | 546 | Protein_24 | IS5 family transposase | - |
| OCUAc17_RS19230 (OCUAc17_37530) | 21770..21997 | + | 228 | WP_005071544.1 | hypothetical protein | - |
| OCUAc17_RS19235 (OCUAc17_37540) | 22107..22316 | - | 210 | WP_000069471.1 | hypothetical protein | - |
| OCUAc17_RS19240 (OCUAc17_37550) | 22309..22611 | - | 303 | WP_001140619.1 | XRE family transcriptional regulator | Antitoxin |
| OCUAc17_RS19245 (OCUAc17_37560) | 22604..22960 | - | 357 | WP_000269903.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| OCUAc17_RS19250 (OCUAc17_37570) | 23670..24206 | + | 537 | WP_009501148.1 | porin family protein | - |
| OCUAc17_RS19255 (OCUAc17_37580) | 24376..24606 | - | 231 | WP_004796422.1 | hypothetical protein | - |
| OCUAc17_RS19260 (OCUAc17_37590) | 24943..25314 | + | 372 | WP_004796420.1 | RcnB family protein | - |
| OCUAc17_RS19265 (OCUAc17_37600) | 25534..26046 | - | 513 | WP_001089572.1 | SMI1/KNR4 family protein | - |
| OCUAc17_RS19270 (OCUAc17_37610) | 26201..26713 | - | 513 | WP_086376834.1 | hypothetical protein | - |
| OCUAc17_RS19275 (OCUAc17_37620) | 26730..27725 | - | 996 | WP_086376833.1 | AraC family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..69156 | 69156 | |
| - | flank | IS/Tn | - | - | 20767..21012 | 245 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 13486.45 Da Isoelectric Point: 7.1645
>T39724 WP_000269903.1 NZ_AP024799:c22960-22604 [Acinetobacter pittii]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG
Download Length: 357 bp
>T39724 NZ_AP024799:c22960-22604 [Acinetobacter pittii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11206.01 Da Isoelectric Point: 6.7282
>AT39724 WP_001140619.1 NZ_AP024799:c22611-22309 [Acinetobacter pittii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
Download Length: 303 bp
>AT39724 NZ_AP024799:c22611-22309 [Acinetobacter pittii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|