Detailed information of TA system TA039425

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1978781..1979436
• Replicon: chromosome
• Accession: NZ_AP024746
• Organism: Bordetella pertussis strain BP616

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: LDO21_RS09615
• Protein ID: WP_047122780.1
• Coordinates: 1978781..1979032 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: LDO21_RS09620
• Protein ID: WP_003809516.1
• Coordinates: 1979035..1979436 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO21_RS09590 (BPJ_19210)	1973942..1975072	-	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-
LDO21_RS09595 (BPJ_19220)	1975307..1975888	+	582	WP_019247931.1	MOSC domain-containing protein	-
LDO21_RS09600 (BPJ_19230)	1976025..1977089	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
LDO21_RS09605 (BPJ_19240)	1977174..1977620	-	447	WP_003819827.1	GFA family protein	-
LDO21_RS09610 (BPJ_19250)	1977845..1978726	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
LDO21_RS09615 (BPJ_19260)	1978781..1979032	+	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
LDO21_RS09620 (BPJ_19270)	1979035..1979436	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
LDO21_RS09625 (BPJ_19280)	1979456..1979692	+	237	WP_010930404.1	DUF5993 family protein	-
LDO21_RS09630 (BPJ_19290)	1979700..1980179	+	480	WP_010930405.1	disulfide bond formation protein B	-
LDO21_RS09635 (BPJ_19300)	1980329..1980844	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
LDO21_RS09640 (BPJ_19310)	1980847..1982037	+	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
LDO21_RS09645 (BPJ_19320)	1982057..1983094	+	1038	WP_023853543.1	L-threonylcarbamoyladenylate synthase	-
LDO21_RS09650 (BPJ_19330)	1983231..1984253	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T39425 WP_047122780.1 NZ_AP024746:1978781-1979032 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T39425 NZ_AP024746:1978781-1979032 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT39425 WP_003809516.1 NZ_AP024746:1979035-1979436 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT39425 NZ_AP024746:1979035-1979436 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6