Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2575033..2575556 Replicon chromosome
Accession NZ_AP024742
Organism Staphylococcus aureus strain 59736

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag OCX51_RS12950 Protein ID WP_000074048.1
Coordinates 2575033..2575299 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag OCX51_RS12955 Protein ID WP_000587616.1
Coordinates 2575299..2575556 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX51_RS12930 (2570339) 2570339..2571526 - 1188 WP_000026194.1 MFS transporter -
OCX51_RS12935 (2571922) 2571922..2572698 - 777 WP_000072145.1 iron export ABC transporter permease subunit FetB -
OCX51_RS12940 (2572691) 2572691..2573353 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
OCX51_RS12945 (2573601) 2573601..2574677 - 1077 WP_001076671.1 M42 family metallopeptidase -
OCX51_RS12950 (2575033) 2575033..2575299 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
OCX51_RS12955 (2575299) 2575299..2575556 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OCX51_RS12960 (2575915) 2575915..2576370 + 456 WP_000732082.1 DUF1307 domain-containing protein -
OCX51_RS12965 (2576538) 2576538..2578115 - 1578 WP_000143496.1 FMN-binding glutamate synthase family protein -
OCX51_RS12970 (2578311) 2578311..2579060 + 750 WP_000072445.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T39421 WP_000074048.1 NZ_AP024742:c2575299-2575033 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T39421 NZ_AP024742:c2575299-2575033 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT39421 WP_000587616.1 NZ_AP024742:c2575556-2575299 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT39421 NZ_AP024742:c2575556-2575299 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References