Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2518486..2519003 | Replicon | chromosome |
| Accession | NZ_AP024742 | ||
| Organism | Staphylococcus aureus strain 59736 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | OCX51_RS12675 | Protein ID | WP_000113262.1 |
| Coordinates | 2518486..2518752 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | OCX51_RS12680 | Protein ID | WP_000584499.1 |
| Coordinates | 2518752..2519003 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OCX51_RS12645 (2513914) | 2513914..2514441 | - | 528 | WP_000973468.1 | GNAT family N-acetyltransferase | - |
| OCX51_RS12650 (2514685) | 2514685..2515509 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| OCX51_RS12655 (2515726) | 2515726..2515908 | - | 183 | WP_000230294.1 | hypothetical protein | - |
| OCX51_RS12660 (2515992) | 2515992..2516459 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| OCX51_RS12665 (2516645) | 2516645..2518192 | - | 1548 | WP_000727756.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| OCX51_RS12670 (2518380) | 2518380..2518451 | - | 72 | WP_223200558.1 | hypothetical protein | - |
| OCX51_RS12675 (2518486) | 2518486..2518752 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| OCX51_RS12680 (2518752) | 2518752..2519003 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| OCX51_RS12685 (2519168) | 2519168..2519248 | - | 81 | WP_223197974.1 | hypothetical protein | - |
| OCX51_RS12690 (2519276) | 2519276..2519875 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| OCX51_RS12695 (2519894) | 2519894..2520256 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| OCX51_RS12700 (2520511) | 2520511..2521761 | + | 1251 | WP_001012222.1 | FemA/FemB family glycyltransferase FmhA | - |
| OCX51_RS12705 (2521858) | 2521858..2522589 | - | 732 | WP_000615458.1 | ATP-binding cassette domain-containing protein | - |
| OCX51_RS12710 (2522586) | 2522586..2523305 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T39418 WP_000113262.1 NZ_AP024742:c2518752-2518486 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T39418 NZ_AP024742:c2518752-2518486 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAAATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAAATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT39418 WP_000584499.1 NZ_AP024742:c2519003-2518752 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT39418 NZ_AP024742:c2519003-2518752 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|