Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) TMCS/-
Location 1599799..1600378 Replicon chromosome
Accession NZ_AP024742
Organism Staphylococcus aureus strain 59736

Toxin (Protein)


Gene name MW1434 Uniprot ID A0A4P7P609
Locus tag OCX51_RS07760 Protein ID WP_001025401.1
Coordinates 1600133..1600378 (-) Length 82 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 1599799..1600164 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX51_RS07720 (1596543) 1596543..1597100 - 558 WP_001668984.1 DUF2815 family protein -
OCX51_RS07725 (1597126) 1597126..1598292 - 1167 WP_000762532.1 DUF2800 domain-containing protein -
OCX51_RS07730 (1598289) 1598289..1598651 - 363 WP_152064739.1 hypothetical protein -
OCX51_RS07735 (1598666) 1598666..1598989 - 324 WP_000174998.1 hypothetical protein -
OCX51_RS07740 (1599067) 1599067..1599228 - 162 WP_001285954.1 DUF1270 domain-containing protein -
OCX51_RS07745 (1599241) 1599241..1599504 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
OCX51_RS07750 (1599529) 1599529..1599744 - 216 WP_001097552.1 hypothetical protein -
OCX51_RS07755 (1599799) 1599799..1600164 + 366 WP_001128433.1 hypothetical protein Antitoxin
OCX51_RS07760 (1600133) 1600133..1600378 - 246 WP_001025401.1 DUF2829 domain-containing protein Toxin
OCX51_RS07765 (1600434) 1600434..1600643 + 210 WP_000642492.1 hypothetical protein -
OCX51_RS07770 (1600633) 1600633..1600776 - 144 WP_000939498.1 hypothetical protein -
OCX51_RS07775 (1600805) 1600805..1601581 - 777 WP_001668987.1 Rha family transcriptional regulator -
OCX51_RS07780 (1601595) 1601595..1601840 - 246 WP_001573844.1 helix-turn-helix transcriptional regulator -
OCX51_RS07785 (1602032) 1602032..1602361 + 330 WP_001573842.1 helix-turn-helix transcriptional regulator -
OCX51_RS07790 (1602374) 1602374..1602835 + 462 WP_001573840.1 phage protein -
OCX51_RS07795 (1602853) 1602853..1603437 + 585 WP_000825948.1 hypothetical protein -
OCX51_RS07800 (1603667) 1603667..1603813 + 147 WP_001013104.1 hypothetical protein -
OCX51_RS07805 (1603810) 1603810..1604424 - 615 WP_000191459.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1560532..1623382 62850


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-69)


Sequences


Toxin        


Download         Length: 82 a.a.        Molecular weight: 9468.72 Da        Isoelectric Point: 5.7783

>T39403 WP_001025401.1 NZ_AP024742:c1600378-1600133 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Download         Length: 246 bp

>T39403 NZ_AP024742:c1600378-1600133 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAGGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin


Download         Length: 366 bp

>AT39403 NZ_AP024742:1599799-1600164 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A4P7P609


Antitoxin

Download structure file

References