Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2514732..2515249 | Replicon | chromosome |
| Accession | NZ_AP024738 | ||
| Organism | Staphylococcus aureus strain 59731 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | OCX20_RS12650 | Protein ID | WP_000113262.1 |
| Coordinates | 2514732..2514998 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | OCX20_RS12655 | Protein ID | WP_000584499.1 |
| Coordinates | 2514998..2515249 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OCX20_RS12620 (2510160) | 2510160..2510687 | - | 528 | WP_000973468.1 | GNAT family N-acetyltransferase | - |
| OCX20_RS12625 (2510931) | 2510931..2511755 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| OCX20_RS12630 (2511972) | 2511972..2512154 | - | 183 | WP_000230294.1 | hypothetical protein | - |
| OCX20_RS12635 (2512238) | 2512238..2512705 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| OCX20_RS12640 (2512891) | 2512891..2514438 | - | 1548 | WP_000727756.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| OCX20_RS12645 (2514626) | 2514626..2514697 | - | 72 | WP_223200558.1 | hypothetical protein | - |
| OCX20_RS12650 (2514732) | 2514732..2514998 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| OCX20_RS12655 (2514998) | 2514998..2515249 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| OCX20_RS12660 (2515414) | 2515414..2515494 | - | 81 | WP_223197974.1 | hypothetical protein | - |
| OCX20_RS12665 (2515522) | 2515522..2516121 | - | 600 | WP_261921286.1 | DsbA family protein | - |
| OCX20_RS12670 (2516140) | 2516140..2516502 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| OCX20_RS12675 (2516757) | 2516757..2518007 | + | 1251 | WP_001012222.1 | FemA/FemB family glycyltransferase FmhA | - |
| OCX20_RS12680 (2518104) | 2518104..2518835 | - | 732 | WP_000615458.1 | ATP-binding cassette domain-containing protein | - |
| OCX20_RS12685 (2518832) | 2518832..2519551 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T39398 WP_000113262.1 NZ_AP024738:c2514998-2514732 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T39398 NZ_AP024738:c2514998-2514732 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAAATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAAATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT39398 WP_000584499.1 NZ_AP024738:c2515249-2514998 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT39398 NZ_AP024738:c2515249-2514998 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|