Detailed information of TA system TA039383

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1598641..1599220
• Replicon: chromosome
• Accession: NZ_AP024738
• Organism: Staphylococcus aureus strain 59731

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: OCX20_RS07750
• Protein ID: WP_001025401.1
• Coordinates: 1598975..1599220 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1598641..1599006 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCX20_RS07710 (1595384)	1595384..1595941	-	558	WP_000645045.1	DUF2815 family protein	-
OCX20_RS07715 (1595967)	1595967..1597133	-	1167	WP_064129389.1	DUF2800 domain-containing protein	-
OCX20_RS07720 (1597130)	1597130..1597492	-	363	WP_000985976.1	hypothetical protein	-
OCX20_RS07725 (1597507)	1597507..1597830	-	324	WP_000174994.1	hypothetical protein	-
OCX20_RS07730 (1597909)	1597909..1598070	-	162	WP_001285963.1	DUF1270 family protein	-
OCX20_RS07735 (1598083)	1598083..1598346	-	264	WP_001124159.1	helix-turn-helix domain-containing protein	-
OCX20_RS07740 (1598371)	1598371..1598586	-	216	WP_001097552.1	hypothetical protein	-
OCX20_RS07745 (1598641)	1598641..1599006	+	366	WP_001128433.1	hypothetical protein	Antitoxin
OCX20_RS07750 (1598975)	1598975..1599220	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
OCX20_RS07755 (1599276)	1599276..1599485	+	210	WP_000642492.1	hypothetical protein	-
OCX20_RS07760 (1599475)	1599475..1599618	-	144	WP_000939498.1	hypothetical protein	-
OCX20_RS07765 (1599647)	1599647..1600423	-	777	WP_001148544.1	Rha family transcriptional regulator	-
OCX20_RS07770 (1600437)	1600437..1600673	-	237	WP_001121027.1	helix-turn-helix transcriptional regulator	-
OCX20_RS07775 (1600825)	1600825..1601139	+	315	WP_000333630.1	helix-turn-helix transcriptional regulator	-
OCX20_RS07780 (1601152)	1601152..1601613	+	462	WP_000525004.1	hypothetical protein	-
OCX20_RS07785 (1601631)	1601631..1602215	+	585	WP_000825948.1	hypothetical protein	-
OCX20_RS07790 (1602445)	1602445..1602591	+	147	WP_072433242.1	hypothetical protein	-
OCX20_RS07795 (1602588)	1602588..1603202	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1556064..1622159	66095

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T39383 WP_001025401.1 NZ_AP024738:c1599220-1598975 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T39383 NZ_AP024738:c1599220-1598975 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAGGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAACGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT39383 NZ_AP024738:1598641-1599006 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin