Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2559541..2560064 Replicon chromosome
Accession NZ_AP024736
Organism Staphylococcus aureus strain 59709

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag OCX48_RS12885 Protein ID WP_000074048.1
Coordinates 2559541..2559807 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag OCX48_RS12890 Protein ID WP_000587616.1
Coordinates 2559807..2560064 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX48_RS12865 (2554847) 2554847..2556034 - 1188 WP_117218875.1 MFS transporter -
OCX48_RS12870 (2556430) 2556430..2557206 - 777 WP_000072145.1 iron export ABC transporter permease subunit FetB -
OCX48_RS12875 (2557199) 2557199..2557861 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
OCX48_RS12880 (2558109) 2558109..2559185 - 1077 WP_001076671.1 M42 family metallopeptidase -
OCX48_RS12885 (2559541) 2559541..2559807 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
OCX48_RS12890 (2559807) 2559807..2560064 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OCX48_RS12895 (2560423) 2560423..2560878 + 456 WP_000732082.1 DUF1307 domain-containing protein -
OCX48_RS12900 (2561046) 2561046..2562623 - 1578 WP_000143496.1 FMN-binding glutamate synthase family protein -
OCX48_RS12905 (2562819) 2562819..2563568 + 750 WP_261934061.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T39381 WP_000074048.1 NZ_AP024736:c2559807-2559541 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T39381 NZ_AP024736:c2559807-2559541 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT39381 WP_000587616.1 NZ_AP024736:c2560064-2559807 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT39381 NZ_AP024736:c2560064-2559807 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References