Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2502994..2503511 | Replicon | chromosome |
| Accession | NZ_AP024736 | ||
| Organism | Staphylococcus aureus strain 59709 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | OCX48_RS12610 | Protein ID | WP_000113262.1 |
| Coordinates | 2502994..2503260 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | OCX48_RS12615 | Protein ID | WP_000584499.1 |
| Coordinates | 2503260..2503511 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OCX48_RS12580 (2498422) | 2498422..2498949 | - | 528 | WP_000973468.1 | GNAT family N-acetyltransferase | - |
| OCX48_RS12585 (2499193) | 2499193..2500017 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| OCX48_RS12590 (2500234) | 2500234..2500416 | - | 183 | WP_000230294.1 | hypothetical protein | - |
| OCX48_RS12595 (2500500) | 2500500..2500967 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| OCX48_RS12600 (2501153) | 2501153..2502700 | - | 1548 | WP_000727756.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| OCX48_RS12605 (2502888) | 2502888..2502959 | - | 72 | WP_223200558.1 | hypothetical protein | - |
| OCX48_RS12610 (2502994) | 2502994..2503260 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| OCX48_RS12615 (2503260) | 2503260..2503511 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| OCX48_RS12620 (2503676) | 2503676..2503756 | - | 81 | WP_223197974.1 | hypothetical protein | - |
| OCX48_RS12625 (2503784) | 2503784..2504383 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| OCX48_RS12630 (2504402) | 2504402..2504764 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| OCX48_RS12635 (2505019) | 2505019..2506269 | + | 1251 | WP_001012222.1 | FemA/FemB family glycyltransferase FmhA | - |
| OCX48_RS12640 (2506366) | 2506366..2507097 | - | 732 | WP_000615458.1 | ATP-binding cassette domain-containing protein | - |
| OCX48_RS12645 (2507094) | 2507094..2507813 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T39378 WP_000113262.1 NZ_AP024736:c2503260-2502994 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T39378 NZ_AP024736:c2503260-2502994 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAAATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAAATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT39378 WP_000584499.1 NZ_AP024736:c2503511-2503260 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT39378 NZ_AP024736:c2503511-2503260 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|