Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2250019..2250235 Replicon chromosome
Accession NZ_AP024736
Organism Staphylococcus aureus strain 59709

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag OCX48_RS11290 Protein ID WP_001802298.1
Coordinates 2250131..2250235 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2250019..2250074 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX48_RS11265 2246279..2246944 - 666 WP_001024095.1 SDR family oxidoreductase -
OCX48_RS11270 2247096..2247416 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
OCX48_RS11275 2247418..2248398 + 981 WP_000019743.1 CDF family zinc efflux transporter CzrB -
OCX48_RS11280 2248664..2249755 + 1092 WP_000495683.1 hypothetical protein -
- 2250019..2250074 + 56 - - Antitoxin
OCX48_RS11290 2250131..2250235 - 105 WP_001802298.1 hypothetical protein Toxin
OCX48_RS11295 2250915..2251073 + 159 WP_001792784.1 hypothetical protein -
OCX48_RS11300 2251732..2252589 - 858 WP_000370917.1 HAD family hydrolase -
OCX48_RS11305 2252657..2253439 - 783 WP_000908178.1 ABC transporter ATP-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.



Sequences


Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T39375 WP_001802298.1 NZ_AP024736:c2250235-2250131 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T39375 NZ_AP024736:c2250235-2250131 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT39375 NZ_AP024736:2250019-2250074 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9


Antitoxin

Download structure file

References