Detailed information of TA system TA039364

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1601815..1602394
• Replicon: chromosome
• Accession: NZ_AP024736
• Organism: Staphylococcus aureus strain 59709

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: OCX48_RS07770
• Protein ID: WP_001025401.1
• Coordinates: 1602149..1602394 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1601815..1602180 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCX48_RS07730 (1598559)	1598559..1599116	-	558	WP_000645045.1	DUF2815 family protein	-
OCX48_RS07735 (1599142)	1599142..1600308	-	1167	WP_000762525.1	DUF2800 domain-containing protein	-
OCX48_RS07740 (1600305)	1600305..1600667	-	363	WP_000279445.1	hypothetical protein	-
OCX48_RS07745 (1600682)	1600682..1601005	-	324	WP_000174995.1	hypothetical protein	-
OCX48_RS07750 (1601084)	1601084..1601245	-	162	WP_015986189.1	DUF1270 family protein	-
OCX48_RS07755 (1601257)	1601257..1601520	-	264	WP_044426023.1	helix-turn-helix domain-containing protein	-
OCX48_RS07760 (1601545)	1601545..1601760	-	216	WP_001097552.1	hypothetical protein	-
OCX48_RS07765 (1601815)	1601815..1602180	+	366	WP_001128433.1	hypothetical protein	Antitoxin
OCX48_RS07770 (1602149)	1602149..1602394	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
OCX48_RS07775 (1602450)	1602450..1602659	+	210	WP_000642492.1	hypothetical protein	-
OCX48_RS07780 (1602649)	1602649..1602792	-	144	WP_000939498.1	hypothetical protein	-
OCX48_RS07785 (1602807)	1602807..1603250	-	444	WP_000435360.1	hypothetical protein	-
OCX48_RS07790 (1603268)	1603268..1603492	-	225	WP_063653167.1	DUF739 family protein	-
OCX48_RS07795 (1603654)	1603654..1604034	+	381	WP_001089477.1	helix-turn-helix domain-containing protein	-
OCX48_RS07800 (1604056)	1604056..1604514	+	459	WP_001558059.1	hypothetical protein	-
OCX48_RS07805 (1604532)	1604532..1604853	+	322	Protein_1532	hypothetical protein	-
OCX48_RS07810 (1604882)	1604882..1605277	+	396	WP_000449655.1	hypothetical protein	-
OCX48_RS07815 (1605367)	1605367..1605513	+	147	WP_001795334.1	hypothetical protein	-
OCX48_RS07820 (1605510)	1605510..1606124	-	615	WP_000191464.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1562127..1620209	58082

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T39364 WP_001025401.1 NZ_AP024736:c1602394-1602149 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T39364 NZ_AP024736:c1602394-1602149 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT39364 NZ_AP024736:1601815-1602180 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin