Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1593780..1594194 Replicon chromosome
Accession NZ_AP024736
Organism Staphylococcus aureus strain 59709

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OCX48_RS07680 Protein ID WP_031267622.1
Coordinates 1593943..1594194 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OCX48_RS07675 Protein ID WP_000028424.1
Coordinates 1593780..1593953 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX48_RS07635 (1589044) 1589044..1589334 - 291 WP_000665205.1 VRR-NUC domain-containing protein -
OCX48_RS07640 (1589468) 1589468..1589566 + 99 WP_001801650.1 hypothetical protein -
OCX48_RS07645 (1589675) 1589675..1592122 - 2448 WP_000884870.1 VapE family protein -
OCX48_RS07650 (1592410) 1592410..1592610 - 201 WP_000265252.1 DUF1514 family protein -
OCX48_RS07655 (1592678) 1592678..1592830 - 153 WP_000595263.1 transcriptional activator RinB -
OCX48_RS07660 (1592827) 1592827..1593033 - 207 WP_000195810.1 DUF1381 domain-containing protein -
OCX48_RS07665 (1593070) 1593070..1593603 - 534 WP_261934054.1 dUTPase -
OCX48_RS07670 (1593618) 1593618..1593779 - 162 WP_000889684.1 hypothetical protein -
OCX48_RS07675 (1593780) 1593780..1593953 - 174 WP_000028424.1 hypothetical protein Antitoxin
OCX48_RS07680 (1593943) 1593943..1594194 - 252 WP_031267622.1 DUF1024 family protein Toxin
OCX48_RS07685 (1594187) 1594187..1594494 - 308 Protein_1508 hypothetical protein -
OCX48_RS07690 (1594491) 1594491..1594838 - 348 WP_000979209.1 YopX family protein -
OCX48_RS07695 (1594835) 1594835..1595215 - 381 WP_001668982.1 hypothetical protein -
OCX48_RS07700 (1595218) 1595218..1595424 - 207 WP_000693989.1 hypothetical protein -
OCX48_RS07705 (1595438) 1595438..1595686 - 249 WP_060474161.1 SAV1978 family virulence-associated passenger protein -
OCX48_RS07710 (1595686) 1595686..1595940 - 255 WP_000022722.1 DUF3310 domain-containing protein -
OCX48_RS07715 (1595937) 1595937..1596341 - 405 WP_044426014.1 SA1788 family PVL leukocidin-associated protein -
OCX48_RS07720 (1596341) 1596341..1596526 - 186 WP_001164629.1 DUF3113 family protein -
OCX48_RS07725 (1596539) 1596539..1598491 - 1953 WP_078064460.1 DNA polymerase -
OCX48_RS07730 (1598559) 1598559..1599116 - 558 WP_000645045.1 DUF2815 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1562127..1620209 58082


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9419.35 Da        Isoelectric Point: 3.9476

>T39363 WP_031267622.1 NZ_AP024736:c1594194-1593943 [Staphylococcus aureus]
MNNREKIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T39363 NZ_AP024736:c1594194-1593943 [Staphylococcus aureus]
ATGAATAATCGCGAAAAAATCGAACAGTCCGTTATTAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT39363 WP_000028424.1 NZ_AP024736:c1593953-1593780 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT39363 NZ_AP024736:c1593953-1593780 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References