39361

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2579811..2580334 Replicon chromosome
Accession NZ_AP024734
Organism Staphylococcus aureus strain 59691

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag OCX19_RS13035 Protein ID WP_000074048.1
Coordinates 2579811..2580077 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag OCX19_RS13040 Protein ID WP_000587616.1
Coordinates 2580077..2580334 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX19_RS13015 (2575117) 2575117..2576304 - 1188 WP_000026194.1 MFS transporter -
OCX19_RS13020 (2576700) 2576700..2577476 - 777 WP_000072145.1 iron export ABC transporter permease subunit FetB -
OCX19_RS13025 (2577469) 2577469..2578131 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
OCX19_RS13030 (2578379) 2578379..2579455 - 1077 WP_001076671.1 M42 family metallopeptidase -
OCX19_RS13035 (2579811) 2579811..2580077 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
OCX19_RS13040 (2580077) 2580077..2580334 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OCX19_RS13045 (2580419) 2580419..2580634 - 216 WP_001793327.1 hypothetical protein -
OCX19_RS13050 (2580693) 2580693..2581148 + 456 WP_000732082.1 DUF1307 domain-containing protein -
OCX19_RS13055 (2581316) 2581316..2582893 - 1578 WP_000143496.1 FMN-binding glutamate synthase family protein -
OCX19_RS13060 (2583089) 2583089..2583838 + 750 WP_000072445.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T39361 WP_000074048.1 NZ_AP024734:c2580077-2579811 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T39361 NZ_AP024734:c2580077-2579811 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT39361 WP_000587616.1 NZ_AP024734:c2580334-2580077 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT39361 NZ_AP024734:c2580334-2580077 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References