Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2523264..2523781 | Replicon | chromosome |
| Accession | NZ_AP024734 | ||
| Organism | Staphylococcus aureus strain 59691 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | OCX19_RS12760 | Protein ID | WP_000113262.1 |
| Coordinates | 2523264..2523530 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | OCX19_RS12765 | Protein ID | WP_000584499.1 |
| Coordinates | 2523530..2523781 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OCX19_RS12730 (2518692) | 2518692..2519219 | - | 528 | WP_000973468.1 | GNAT family N-acetyltransferase | - |
| OCX19_RS12735 (2519463) | 2519463..2520287 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| OCX19_RS12740 (2520504) | 2520504..2520686 | - | 183 | WP_000230294.1 | hypothetical protein | - |
| OCX19_RS12745 (2520770) | 2520770..2521237 | - | 468 | WP_031898730.1 | SRPBCC domain-containing protein | - |
| OCX19_RS12750 (2521423) | 2521423..2522970 | - | 1548 | WP_000727756.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| OCX19_RS12755 (2523158) | 2523158..2523229 | - | 72 | WP_223200558.1 | hypothetical protein | - |
| OCX19_RS12760 (2523264) | 2523264..2523530 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| OCX19_RS12765 (2523530) | 2523530..2523781 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| OCX19_RS12770 (2523946) | 2523946..2524026 | - | 81 | WP_223197974.1 | hypothetical protein | - |
| OCX19_RS12775 (2524054) | 2524054..2524653 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| OCX19_RS12780 (2524672) | 2524672..2525034 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| OCX19_RS12785 (2525289) | 2525289..2526539 | + | 1251 | WP_001012222.1 | FemA/FemB family glycyltransferase FmhA | - |
| OCX19_RS12790 (2526636) | 2526636..2527367 | - | 732 | WP_000615458.1 | ATP-binding cassette domain-containing protein | - |
| OCX19_RS12795 (2527364) | 2527364..2528083 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T39358 WP_000113262.1 NZ_AP024734:c2523530-2523264 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T39358 NZ_AP024734:c2523530-2523264 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAAATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAAATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT39358 WP_000584499.1 NZ_AP024734:c2523781-2523530 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT39358 NZ_AP024734:c2523781-2523530 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|