Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | txpA-MW1433/- |
| Location | 2096234..2096541 | Replicon | chromosome |
| Accession | NZ_AP024734 | ||
| Organism | Staphylococcus aureus strain 59691 | ||
Toxin (Protein)
| Gene name | txpA | Uniprot ID | Q2FWU9 |
| Locus tag | OCX19_RS10455 | Protein ID | WP_011447039.1 |
| Coordinates | 2096365..2096541 (-) | Length | 59 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 2096234..2096373 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OCX19_RS10415 (2091799) | 2091799..2091978 | + | 180 | WP_000669791.1 | hypothetical protein | - |
| OCX19_RS10420 (2092289) | 2092289..2092549 | + | 261 | WP_001791826.1 | hypothetical protein | - |
| OCX19_RS10425 (2092602) | 2092602..2092952 | - | 351 | WP_000702263.1 | complement inhibitor SCIN-A | - |
| OCX19_RS10430 (2093464) | 2093464..2093799 | - | 336 | Protein_2017 | SH3 domain-containing protein | - |
| OCX19_RS10435 (2094450) | 2094450..2094941 | - | 492 | WP_000920038.1 | staphylokinase | - |
| OCX19_RS10440 (2095132) | 2095132..2095887 | - | 756 | WP_000861038.1 | CHAP domain-containing protein | - |
| OCX19_RS10445 (2095899) | 2095899..2096153 | - | 255 | WP_000611512.1 | phage holin | - |
| OCX19_RS10450 (2096205) | 2096205..2096312 | + | 108 | WP_031762631.1 | hypothetical protein | - |
| - (2096234) | 2096234..2096373 | + | 140 | NuclAT_0 | - | Antitoxin |
| - (2096234) | 2096234..2096373 | + | 140 | NuclAT_0 | - | Antitoxin |
| - (2096234) | 2096234..2096373 | + | 140 | NuclAT_0 | - | Antitoxin |
| - (2096234) | 2096234..2096373 | + | 140 | NuclAT_0 | - | Antitoxin |
| OCX19_RS10455 (2096365) | 2096365..2096541 | - | 177 | WP_011447039.1 | type I toxin-antitoxin system toxin PepG1 | Toxin |
| OCX19_RS10460 (2096691) | 2096691..2096987 | - | 297 | WP_000539688.1 | DUF2951 domain-containing protein | - |
| OCX19_RS10465 (2097045) | 2097045..2097332 | - | 288 | WP_001040261.1 | hypothetical protein | - |
| OCX19_RS10470 (2097379) | 2097379..2097531 | - | 153 | WP_001153681.1 | hypothetical protein | - |
| OCX19_RS10475 (2097521) | 2097521..2101306 | - | 3786 | WP_000582158.1 | phage tail spike protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | scn / sak / hlb / groEL | 2092602..2148746 | 56144 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6849.45 Da Isoelectric Point: 10.6777
>T39350 WP_011447039.1 NZ_AP024734:c2096541-2096365 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
Download Length: 177 bp
>T39350 NZ_AP024734:c2096541-2096365 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
Antitoxin
Download Length: 140 bp
>AT39350 NZ_AP024734:2096234-2096373 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
