39325

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2565403..2565926 Replicon chromosome
Accession NZ_AP024730
Organism Staphylococcus aureus strain 59574

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag OCX16_RS12905 Protein ID WP_000074048.1
Coordinates 2565403..2565669 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag OCX16_RS12910 Protein ID WP_000587616.1
Coordinates 2565669..2565926 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX16_RS12885 (2560709) 2560709..2561896 - 1188 WP_117218875.1 MFS transporter -
OCX16_RS12890 (2562292) 2562292..2563068 - 777 WP_000072145.1 iron export ABC transporter permease subunit FetB -
OCX16_RS12895 (2563061) 2563061..2563723 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
OCX16_RS12900 (2563971) 2563971..2565047 - 1077 WP_001076671.1 M42 family metallopeptidase -
OCX16_RS12905 (2565403) 2565403..2565669 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
OCX16_RS12910 (2565669) 2565669..2565926 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OCX16_RS12915 (2566285) 2566285..2566740 + 456 WP_000732082.1 DUF1307 domain-containing protein -
OCX16_RS12920 (2566908) 2566908..2568485 - 1578 WP_000143496.1 FMN-binding glutamate synthase family protein -
OCX16_RS12925 (2568681) 2568681..2569430 + 750 WP_000072445.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T39325 WP_000074048.1 NZ_AP024730:c2565669-2565403 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T39325 NZ_AP024730:c2565669-2565403 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT39325 WP_000587616.1 NZ_AP024730:c2565926-2565669 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT39325 NZ_AP024730:c2565926-2565669 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References