Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2534213..2534397 Replicon chromosome
Accession NZ_AP024730
Organism Staphylococcus aureus strain 59574

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag OCX16_RS12765 Protein ID WP_000482647.1
Coordinates 2534290..2534397 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2534213..2534273 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX16_RS12750 2529687..2529854 - 168 WP_001790576.1 hypothetical protein -
OCX16_RS12755 2530085..2531818 - 1734 WP_000486494.1 ABC transporter ATP-binding protein -
OCX16_RS12760 2531843..2533606 - 1764 WP_001064816.1 ABC transporter ATP-binding protein -
- 2534213..2534273 + 61 - - Antitoxin
OCX16_RS12765 2534290..2534397 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
OCX16_RS12770 2534531..2534917 - 387 WP_000779360.1 flippase GtxA -
OCX16_RS12775 2535175..2536317 + 1143 WP_001176871.1 glycerate kinase -
OCX16_RS12780 2536377..2537036 + 660 WP_000831301.1 membrane protein -
OCX16_RS12785 2537218..2538429 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
OCX16_RS12790 2538552..2539025 - 474 WP_000456497.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T39323 WP_000482647.1 NZ_AP024730:c2534397-2534290 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T39323 NZ_AP024730:c2534397-2534290 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT39323 NZ_AP024730:2534213-2534273 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References