Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | txpA-MW1433/- |
| Location | 2081991..2082298 | Replicon | chromosome |
| Accession | NZ_AP024730 | ||
| Organism | Staphylococcus aureus strain 59574 | ||
Toxin (Protein)
| Gene name | txpA | Uniprot ID | Q2FWU9 |
| Locus tag | OCX16_RS10350 | Protein ID | WP_011447039.1 |
| Coordinates | 2082122..2082298 (-) | Length | 59 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 2081991..2082130 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OCX16_RS10305 (2076991) | 2076991..2077188 | + | 198 | WP_000239610.1 | phospholipase | - |
| OCX16_RS10310 (2077560) | 2077560..2077739 | + | 180 | WP_000669791.1 | hypothetical protein | - |
| OCX16_RS10315 (2078050) | 2078050..2078310 | + | 261 | WP_001791826.1 | hypothetical protein | - |
| OCX16_RS10320 (2078363) | 2078363..2078713 | - | 351 | WP_000702263.1 | complement inhibitor SCIN-A | - |
| OCX16_RS10325 (2079225) | 2079225..2079560 | - | 336 | Protein_1996 | SH3 domain-containing protein | - |
| OCX16_RS10330 (2080211) | 2080211..2080702 | - | 492 | WP_000920038.1 | staphylokinase | - |
| OCX16_RS10335 (2080893) | 2080893..2081648 | - | 756 | WP_000861038.1 | CHAP domain-containing protein | - |
| OCX16_RS10340 (2081660) | 2081660..2081914 | - | 255 | WP_000611512.1 | phage holin | - |
| OCX16_RS10345 (2081962) | 2081962..2082069 | + | 108 | WP_031762631.1 | hypothetical protein | - |
| - (2081991) | 2081991..2082130 | + | 140 | NuclAT_0 | - | Antitoxin |
| - (2081991) | 2081991..2082130 | + | 140 | NuclAT_0 | - | Antitoxin |
| - (2081991) | 2081991..2082130 | + | 140 | NuclAT_0 | - | Antitoxin |
| - (2081991) | 2081991..2082130 | + | 140 | NuclAT_0 | - | Antitoxin |
| OCX16_RS10350 (2082122) | 2082122..2082298 | - | 177 | WP_011447039.1 | type I toxin-antitoxin system toxin PepG1 | Toxin |
| OCX16_RS10355 (2082407) | 2082407..2083180 | - | 774 | WP_000750412.1 | staphylococcal enterotoxin type A | - |
| OCX16_RS10360 (2083553) | 2083553..2083927 | - | 375 | WP_000340977.1 | hypothetical protein | - |
| OCX16_RS10365 (2083983) | 2083983..2084270 | - | 288 | WP_001262621.1 | hypothetical protein | - |
| OCX16_RS10370 (2084316) | 2084316..2084468 | - | 153 | WP_001000058.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | map / hlb / scn / sak / sea / selq / selk / hlb / groEL / hld | 2028195..2150407 | 122212 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6849.45 Da Isoelectric Point: 10.6777
>T39314 WP_011447039.1 NZ_AP024730:c2082298-2082122 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
Download Length: 177 bp
>T39314 NZ_AP024730:c2082298-2082122 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
Antitoxin
Download Length: 140 bp
>AT39314 NZ_AP024730:2081991-2082130 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
