Detailed information of TA system TA039307

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1593303..1593882
• Replicon: chromosome
• Accession: NZ_AP024730
• Organism: Staphylococcus aureus strain 59574

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: OCX16_RS07730
• Protein ID: WP_001025401.1
• Coordinates: 1593637..1593882 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1593303..1593668 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCX16_RS07690 (1590046)	1590046..1590603	-	558	WP_000645045.1	DUF2815 family protein	-
OCX16_RS07695 (1590629)	1590629..1591795	-	1167	WP_064129389.1	DUF2800 domain-containing protein	-
OCX16_RS07700 (1591792)	1591792..1592154	-	363	WP_000985976.1	hypothetical protein	-
OCX16_RS07705 (1592169)	1592169..1592492	-	324	WP_000174994.1	hypothetical protein	-
OCX16_RS07710 (1592571)	1592571..1592732	-	162	WP_001285963.1	DUF1270 family protein	-
OCX16_RS07715 (1592745)	1592745..1593008	-	264	WP_001124159.1	helix-turn-helix domain-containing protein	-
OCX16_RS07720 (1593033)	1593033..1593248	-	216	WP_001097552.1	hypothetical protein	-
OCX16_RS07725 (1593303)	1593303..1593668	+	366	WP_001128433.1	hypothetical protein	Antitoxin
OCX16_RS07730 (1593637)	1593637..1593882	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
OCX16_RS07735 (1593938)	1593938..1594147	+	210	WP_000642492.1	hypothetical protein	-
OCX16_RS07740 (1594137)	1594137..1594280	-	144	WP_000939498.1	hypothetical protein	-
OCX16_RS07745 (1594309)	1594309..1595085	-	777	WP_001148544.1	Rha family transcriptional regulator	-
OCX16_RS07750 (1595099)	1595099..1595335	-	237	WP_001121027.1	helix-turn-helix transcriptional regulator	-
OCX16_RS07755 (1595487)	1595487..1595801	+	315	WP_000333630.1	helix-turn-helix transcriptional regulator	-
OCX16_RS07760 (1595814)	1595814..1596275	+	462	WP_000525004.1	hypothetical protein	-
OCX16_RS07765 (1596293)	1596293..1596877	+	585	WP_000825948.1	hypothetical protein	-
OCX16_RS07770 (1597107)	1597107..1597253	+	147	WP_072433242.1	hypothetical protein	-
OCX16_RS07775 (1597250)	1597250..1597864	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	gnd	1554568..1621778	67210

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T39307 WP_001025401.1 NZ_AP024730:c1593882-1593637 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T39307 NZ_AP024730:c1593882-1593637 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAGGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAACGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT39307 NZ_AP024730:1593303-1593668 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin