Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2527481..2528004 Replicon chromosome
Accession NZ_AP024728
Organism Staphylococcus aureus strain 59553

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag OCX18_RS12615 Protein ID WP_000074048.1
Coordinates 2527481..2527747 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag OCX18_RS12620 Protein ID WP_000587616.1
Coordinates 2527747..2528004 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX18_RS12595 (2522787) 2522787..2523974 - 1188 WP_000026194.1 MFS transporter -
OCX18_RS12600 (2524370) 2524370..2525146 - 777 WP_000072145.1 iron export ABC transporter permease subunit FetB -
OCX18_RS12605 (2525139) 2525139..2525801 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
OCX18_RS12610 (2526049) 2526049..2527125 - 1077 WP_001076671.1 M42 family metallopeptidase -
OCX18_RS12615 (2527481) 2527481..2527747 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
OCX18_RS12620 (2527747) 2527747..2528004 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OCX18_RS12625 (2528363) 2528363..2528818 + 456 WP_000732082.1 DUF1307 domain-containing protein -
OCX18_RS12630 (2528986) 2528986..2530563 - 1578 WP_000143496.1 FMN-binding glutamate synthase family protein -
OCX18_RS12635 (2530759) 2530759..2531508 + 750 WP_000072445.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T39305 WP_000074048.1 NZ_AP024728:c2527747-2527481 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T39305 NZ_AP024728:c2527747-2527481 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT39305 WP_000587616.1 NZ_AP024728:c2528004-2527747 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT39305 NZ_AP024728:c2528004-2527747 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References