Detailed information of TA system TA039303

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2496291..2496475
• Replicon: chromosome
• Accession: NZ_AP024728
• Organism: Staphylococcus aureus strain 59553

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: OCX18_RS12475
• Protein ID: WP_000482647.1
• Coordinates: 2496368..2496475 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2496291..2496351 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCX18_RS12460	2491765..2491932	-	168	WP_001790576.1	hypothetical protein	-
OCX18_RS12465	2492163..2493896	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
OCX18_RS12470	2493921..2495684	-	1764	WP_001064816.1	ABC transporter ATP-binding protein	-
-	2496291..2496351	+	61	-	-	Antitoxin
OCX18_RS12475	2496368..2496475	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
OCX18_RS12480	2496609..2496995	-	387	WP_000779360.1	flippase GtxA	-
OCX18_RS12485	2497253..2498395	+	1143	WP_001176871.1	glycerate kinase	-
OCX18_RS12490	2498455..2499114	+	660	WP_000831301.1	membrane protein	-
OCX18_RS12495	2499296..2500507	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
OCX18_RS12500	2500630..2501103	-	474	WP_000456497.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T39303 WP_000482647.1 NZ_AP024728:c2496475-2496368 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T39303 NZ_AP024728:c2496475-2496368 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT39303 NZ_AP024728:2496291-2496351 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin