Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprG3-sprA1AS/-
Location 2217854..2218051 Replicon chromosome
Accession NZ_AP024728
Organism Staphylococcus aureus strain 59553

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag OCX18_RS11020 Protein ID WP_001802298.1
Coordinates 2217947..2218051 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 2217854..2217892 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX18_RS10995 2214095..2214760 - 666 WP_001024095.1 SDR family oxidoreductase -
OCX18_RS11000 2214912..2215232 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
OCX18_RS11005 2215234..2216214 + 981 WP_000019743.1 CDF family zinc efflux transporter CzrB -
OCX18_RS11010 2216480..2217571 + 1092 WP_000495683.1 hypothetical protein -
OCX18_RS11015 2217834..2217908 + 75 Protein_2130 hypothetical protein -
- 2217854..2217892 + 39 - - Antitoxin
OCX18_RS11020 2217947..2218051 - 105 WP_001802298.1 hypothetical protein Toxin
OCX18_RS11025 2218731..2218889 + 159 WP_001792784.1 hypothetical protein -
OCX18_RS11030 2219548..2220405 - 858 WP_000370917.1 HAD family hydrolase -
OCX18_RS11035 2220473..2221255 - 783 WP_000908178.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T39301 WP_001802298.1 NZ_AP024728:c2218051-2217947 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T39301 NZ_AP024728:c2218051-2217947 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 39 bp

>AT39301 NZ_AP024728:2217854-2217892 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References