39289

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2551852..2552375 Replicon chromosome
Accession NZ_AP024726
Organism Staphylococcus aureus strain 59482

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag OCX11_RS12855 Protein ID WP_000074048.1
Coordinates 2551852..2552118 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag OCX11_RS12860 Protein ID WP_000587616.1
Coordinates 2552118..2552375 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX11_RS12835 (2547158) 2547158..2548345 - 1188 WP_000026194.1 MFS transporter -
OCX11_RS12840 (2548741) 2548741..2549517 - 777 WP_000072145.1 iron export ABC transporter permease subunit FetB -
OCX11_RS12845 (2549510) 2549510..2550172 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
OCX11_RS12850 (2550420) 2550420..2551496 - 1077 WP_001076671.1 M42 family metallopeptidase -
OCX11_RS12855 (2551852) 2551852..2552118 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
OCX11_RS12860 (2552118) 2552118..2552375 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OCX11_RS12865 (2552460) 2552460..2552675 - 216 WP_001793327.1 hypothetical protein -
OCX11_RS12870 (2552734) 2552734..2553189 + 456 WP_000732082.1 DUF1307 domain-containing protein -
OCX11_RS12875 (2553357) 2553357..2554934 - 1578 WP_000143496.1 FMN-binding glutamate synthase family protein -
OCX11_RS12880 (2555130) 2555130..2555879 + 750 WP_000072445.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T39289 WP_000074048.1 NZ_AP024726:c2552118-2551852 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T39289 NZ_AP024726:c2552118-2551852 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT39289 WP_000587616.1 NZ_AP024726:c2552375-2552118 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT39289 NZ_AP024726:c2552375-2552118 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References