Detailed information of TA system TA039272

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1584180..1584759
• Replicon: chromosome
• Accession: NZ_AP024726
• Organism: Staphylococcus aureus strain 59482

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: OCX11_RS07700
• Protein ID: WP_001025401.1
• Coordinates: 1584514..1584759 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1584180..1584545 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCX11_RS07660 (1580923)	1580923..1581480	-	558	WP_000645045.1	DUF2815 family protein	-
OCX11_RS07665 (1581506)	1581506..1582672	-	1167	WP_064129389.1	DUF2800 domain-containing protein	-
OCX11_RS07670 (1582669)	1582669..1583031	-	363	WP_000985976.1	hypothetical protein	-
OCX11_RS07675 (1583046)	1583046..1583369	-	324	WP_000174994.1	hypothetical protein	-
OCX11_RS07680 (1583448)	1583448..1583609	-	162	WP_001285963.1	DUF1270 family protein	-
OCX11_RS07685 (1583622)	1583622..1583885	-	264	WP_001124159.1	helix-turn-helix domain-containing protein	-
OCX11_RS07690 (1583910)	1583910..1584125	-	216	WP_001097552.1	hypothetical protein	-
OCX11_RS07695 (1584180)	1584180..1584545	+	366	WP_001128433.1	hypothetical protein	Antitoxin
OCX11_RS07700 (1584514)	1584514..1584759	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
OCX11_RS07705 (1584815)	1584815..1585024	+	210	WP_000642492.1	hypothetical protein	-
OCX11_RS07710 (1585014)	1585014..1585157	-	144	WP_000939498.1	hypothetical protein	-
OCX11_RS07715 (1585186)	1585186..1585962	-	777	WP_001148544.1	Rha family transcriptional regulator	-
OCX11_RS07720 (1585976)	1585976..1586212	-	237	WP_001121027.1	helix-turn-helix transcriptional regulator	-
OCX11_RS07725 (1586364)	1586364..1586678	+	315	WP_000333630.1	helix-turn-helix transcriptional regulator	-
OCX11_RS07730 (1586691)	1586691..1587152	+	462	WP_000525004.1	hypothetical protein	-
OCX11_RS07735 (1587170)	1587170..1587754	+	585	WP_000825948.1	hypothetical protein	-
OCX11_RS07740 (1587984)	1587984..1588130	+	147	WP_072433242.1	hypothetical protein	-
OCX11_RS07745 (1588127)	1588127..1588741	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1544546..1609392	64846

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T39272 WP_001025401.1 NZ_AP024726:c1584759-1584514 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T39272 NZ_AP024726:c1584759-1584514 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAGGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAACGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT39272 NZ_AP024726:1584180-1584545 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin