Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2509317..2509834 | Replicon | chromosome |
| Accession | NZ_AP024723 | ||
| Organism | Staphylococcus aureus strain 59458 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | OCX22_RS12640 | Protein ID | WP_000113262.1 |
| Coordinates | 2509317..2509583 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | OCX22_RS12645 | Protein ID | WP_000584499.1 |
| Coordinates | 2509583..2509834 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OCX22_RS12610 (2504892) | 2504892..2505419 | - | 528 | WP_000973468.1 | GNAT family N-acetyltransferase | - |
| OCX22_RS12615 (2505663) | 2505663..2506487 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| OCX22_RS12620 (2506570) | 2506570..2506755 | - | 186 | WP_261921378.1 | hypothetical protein | - |
| OCX22_RS12625 (2506839) | 2506839..2507290 | - | 452 | Protein_2442 | SRPBCC domain-containing protein | - |
| OCX22_RS12630 (2507476) | 2507476..2509023 | - | 1548 | WP_000727756.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| OCX22_RS12635 (2509211) | 2509211..2509282 | - | 72 | WP_223200558.1 | hypothetical protein | - |
| OCX22_RS12640 (2509317) | 2509317..2509583 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| OCX22_RS12645 (2509583) | 2509583..2509834 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| OCX22_RS12650 (2509999) | 2509999..2510079 | - | 81 | WP_223197974.1 | hypothetical protein | - |
| OCX22_RS12655 (2510107) | 2510107..2510706 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| OCX22_RS12660 (2510725) | 2510725..2511087 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| OCX22_RS12665 (2511342) | 2511342..2512592 | + | 1251 | WP_001012222.1 | FemA/FemB family glycyltransferase FmhA | - |
| OCX22_RS12670 (2512689) | 2512689..2513420 | - | 732 | WP_000615458.1 | ATP-binding cassette domain-containing protein | - |
| OCX22_RS12675 (2513417) | 2513417..2514136 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T39267 WP_000113262.1 NZ_AP024723:c2509583-2509317 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T39267 NZ_AP024723:c2509583-2509317 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAAATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAAATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT39267 WP_000584499.1 NZ_AP024723:c2509834-2509583 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT39267 NZ_AP024723:c2509834-2509583 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|