Detailed information of TA system TA039252

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1595479..1596058
• Replicon: chromosome
• Accession: NZ_AP024723
• Organism: Staphylococcus aureus strain 59458

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: OCX22_RS07745
• Protein ID: WP_001025401.1
• Coordinates: 1595813..1596058 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1595479..1595844 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCX22_RS07705 (1592222)	1592222..1592779	-	558	WP_000645042.1	DUF2815 family protein	-
OCX22_RS07710 (1592805)	1592805..1593971	-	1167	WP_000762547.1	DUF2800 domain-containing protein	-
OCX22_RS07715 (1593968)	1593968..1594330	-	363	WP_000985984.1	hypothetical protein	-
OCX22_RS07720 (1594345)	1594345..1594668	-	324	WP_000175001.1	hypothetical protein	-
OCX22_RS07725 (1594747)	1594747..1594908	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
OCX22_RS07730 (1594921)	1594921..1595184	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
OCX22_RS07735 (1595209)	1595209..1595424	-	216	WP_001097552.1	hypothetical protein	-
OCX22_RS07740 (1595479)	1595479..1595844	+	366	WP_001128433.1	hypothetical protein	Antitoxin
OCX22_RS07745 (1595813)	1595813..1596058	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
OCX22_RS07750 (1596114)	1596114..1596323	+	210	WP_000642492.1	hypothetical protein	-
OCX22_RS07755 (1596313)	1596313..1596456	-	144	WP_000939498.1	hypothetical protein	-
OCX22_RS07760 (1596485)	1596485..1597261	-	777	WP_001148544.1	Rha family transcriptional regulator	-
OCX22_RS07765 (1597275)	1597275..1597511	-	237	WP_001121027.1	helix-turn-helix transcriptional regulator	-
OCX22_RS07770 (1597663)	1597663..1597977	+	315	WP_000333630.1	helix-turn-helix transcriptional regulator	-
OCX22_RS07775 (1597990)	1597990..1598451	+	462	WP_000525004.1	hypothetical protein	-
OCX22_RS07780 (1598469)	1598469..1599053	+	585	WP_000825948.1	hypothetical protein	-
OCX22_RS07785 (1599283)	1599283..1599429	+	147	WP_261921362.1	hypothetical protein	-
OCX22_RS07790 (1599426)	1599426..1600040	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1553277..1618998	65721

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T39252 WP_001025401.1 NZ_AP024723:c1596058-1595813 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T39252 NZ_AP024723:c1596058-1595813 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT39252 NZ_AP024723:1595479-1595844 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin