Detailed information of TA system TA039242

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Gp49-HTH_37
• Location: 756361..756958
• Replicon: chromosome
• Accession: NZ_AP024713
• Organism: Campylobacter sp. 19-13652

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LBC_RS03735
• Protein ID: WP_221254765.1
• Coordinates: 756361..756687 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LBC_RS03740
• Protein ID: WP_221254766.1
• Coordinates: 756671..756958 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LBC_RS03705 (LBC_07240)	752227..752889	+	663	WP_221254759.1	hypothetical protein	-
LBC_RS03710 (LBC_07250)	752886..753101	+	216	WP_221254760.1	hypothetical protein	-
LBC_RS03715 (LBC_07260)	753098..753589	+	492	WP_221254761.1	hypothetical protein	-
LBC_RS03720 (LBC_07270)	753582..753896	+	315	WP_221254762.1	hypothetical protein	-
LBC_RS03725 (LBC_07280)	753859..754368	+	510	WP_221254763.1	hypothetical protein	-
LBC_RS03730 (LBC_07290)	754365..756314	+	1950	WP_221254764.1	phage terminase large subunit family protein	-
LBC_RS03735 (LBC_07300)	756361..756687	+	327	WP_221254765.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LBC_RS03740 (LBC_07310)	756671..756958	+	288	WP_221254766.1	helix-turn-helix transcriptional regulator	Antitoxin
LBC_RS03745 (LBC_07320)	757081..757866	-	786	WP_221254767.1	hypothetical protein	-
LBC_RS03750 (LBC_07330)	758292..758690	+	399	WP_221254768.1	hypothetical protein	-
LBC_RS03755 (LBC_07340)	758891..759136	+	246	WP_221254769.1	hypothetical protein	-
LBC_RS03760 (LBC_07350)	759319..759513	+	195	WP_221254770.1	hypothetical protein	-
LBC_RS03765 (LBC_07360)	759541..759738	+	198	WP_221254771.1	hypothetical protein	-
LBC_RS03770 (LBC_07370)	759735..759878	+	144	WP_221254772.1	hypothetical protein	-
LBC_RS03775 (LBC_07380)	760826..761275	+	450	WP_221254773.1	hypothetical protein	-
LBC_RS03780 (LBC_07390)	761279..761620	+	342	WP_221254774.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (15-101)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-89)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12314.44 Da
• Isoelectric Point: 8.9488

>T39242 WP_221254765.1 NZ_AP024713:756361-756687 [Campylobacter sp. 19-13652]
MKFEVSFINETAEAEFLSLPDGLKARGVYMIDMLELGLRGEPHTKALDDGLFELRIKSKEGIARSLFCYQIGSRIVILRT
FIKKDNKIPSNELKIAKARLKELNDDKL

Nucleotide

• Length: 327 bp

>T39242 NZ_AP024713:756361-756687 [Campylobacter sp. 19-13652]
ATGAAATTTGAAGTATCTTTTATAAATGAGACGGCAGAAGCGGAGTTTTTAAGCTTGCCTGATGGTTTAAAAGCTCGTGG
CGTGTATATGATTGATATGCTTGAGCTTGGCTTGCGTGGTGAGCCACATACCAAAGCTTTGGATGATGGGCTATTTGAAC
TACGTATTAAGTCCAAAGAGGGCATAGCAAGGAGCCTATTTTGTTATCAAATCGGCTCACGCATAGTGATTTTACGCACC
TTTATTAAAAAGGACAATAAAATCCCAAGCAATGAGCTAAAAATCGCCAAAGCTAGACTAAAGGAGCTAAATGATGATAA
GCTTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10716.59 Da
• Isoelectric Point: 10.2411

>AT39242 WP_221254766.1 NZ_AP024713:756671-756958 [Campylobacter sp. 19-13652]
MMISFKQTKDKLLKDPAFKAEYEKAKVELETEFALLDSLKQARNESKLTQAEIAQRMGTKQSAVARLEAGVFNAKLDTII
RYARAIGLKELKIAL

Nucleotide

• Length: 288 bp

>AT39242 NZ_AP024713:756671-756958 [Campylobacter sp. 19-13652]
ATGATGATAAGCTTTAAACAGACTAAGGATAAGCTACTAAAAGACCCAGCCTTTAAGGCGGAGTACGAAAAGGCAAAAGT
CGAGCTAGAAACGGAGTTTGCCCTGCTTGATAGCCTAAAGCAGGCTAGAAATGAGAGCAAACTAACTCAGGCTGAAATAG
CCCAGCGTATGGGGACAAAACAATCTGCCGTCGCTAGACTGGAGGCTGGCGTGTTTAATGCCAAACTAGATACCATTATC
CGCTATGCACGAGCGATTGGGCTAAAAGAGCTTAAGATAGCATTGTAG