Detailed information of TA system TA039240

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 2185997..2186582
• Replicon: chromosome
• Accession: NZ_AP024708
• Organism: Acinetobacter sp. Tol 5

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: TOL5_RS10090
• Protein ID: WP_121774457.1
• Coordinates: 2186262..2186582 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A8I1A8A3
• Locus tag: TOL5_RS10085
• Protein ID: WP_058971122.1
• Coordinates: 2185997..2186269 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TOL5_RS10070 (TOL5_19610)	2181701..2183902	-	2202	WP_100885315.1	glycerol-3-phosphate 1-O-acyltransferase PlsB	-
TOL5_RS10075 (TOL5_19620)	2184136..2185134	+	999	WP_042088689.1	cysteine synthase A	-
TOL5_RS10080 (TOL5_19630)	2185409..2185915	-	507	WP_121774458.1	AAA family ATPase	-
TOL5_RS10085 (TOL5_19640)	2185997..2186269	-	273	WP_058971122.1	NadS family protein	Antitoxin
TOL5_RS10090 (TOL5_19650)	2186262..2186582	-	321	WP_121774457.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
TOL5_RS10095 (TOL5_19660)	2186967..2187503	-	537	WP_121774456.1	transglycosylase SLT domain-containing protein	-
TOL5_RS10100 (TOL5_19670)	2187821..2188183	+	363	WP_227543981.1	hypothetical protein	-
TOL5_RS10105 (TOL5_19680)	2188366..2190990	+	2625	WP_121774455.1	type VI secretion system Vgr family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (40-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-75)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12187.02 Da
• Isoelectric Point: 7.1644

>T39240 WP_121774457.1 NZ_AP024708:c2186582-2186262 [Acinetobacter sp. Tol 5]
MLFIETSIFTKQIKELVTDDEYRQLQQDLLVEPDKGDVIKNGGGIRKVRCAQGNKAKSGGIRVIYYWVSEDDHIFFLVAY
PKSMKDNLTDKETAILRQLVKEQLHG

Nucleotide

• Length: 321 bp

>T39240 NZ_AP024708:c2186582-2186262 [Acinetobacter sp. Tol 5]
ATGTTATTTATTGAAACCAGTATTTTTACCAAACAAATCAAAGAACTTGTTACTGATGATGAATATCGCCAGTTACAGCA
AGATCTTTTGGTAGAGCCTGATAAAGGTGATGTGATAAAAAATGGTGGTGGAATACGAAAAGTACGTTGTGCTCAAGGCA
ATAAAGCAAAAAGTGGTGGTATCCGTGTAATCTATTATTGGGTTTCAGAAGATGACCATATTTTCTTTTTAGTGGCTTAT
CCCAAGTCTATGAAAGACAATTTAACGGATAAAGAAACTGCAATTCTACGTCAATTAGTGAAGGAGCAACTTCATGGATA
A

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10135.62 Da
• Isoelectric Point: 9.9218

>AT39240 WP_058971122.1 NZ_AP024708:c2186269-2185997 [Acinetobacter sp. Tol 5]
MDNTLFDDLVSSIKEAGAIKRKEIQASRVTELVLPNIKDVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Nucleotide

• Length: 273 bp

>AT39240 NZ_AP024708:c2186269-2185997 [Acinetobacter sp. Tol 5]
ATGGATAATACTTTATTTGATGACCTCGTTTCTTCGATTAAAGAAGCAGGTGCAATTAAGCGTAAAGAGATTCAGGCAAG
TCGTGTAACAGAACTGGTATTACCTAATATTAAGGACGTACGTGAAAAAACGGGTTTGAGCCAAAATGAATTTGCTGCAC
GCTTGCATATTAGCCCTCGTACTCTACAGAATTGGGAACAAGGTAGACGTTATCCAACAGGCCCAGCAGCGACATTAATT
CGCATTCTAGATGCCCATCCAACTCTGATTTAA