Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2185997..2186582 Replicon chromosome
Accession NZ_AP024708
Organism Acinetobacter sp. Tol 5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag TOL5_RS10090 Protein ID WP_121774457.1
Coordinates 2186262..2186582 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8I1A8A3
Locus tag TOL5_RS10085 Protein ID WP_058971122.1
Coordinates 2185997..2186269 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TOL5_RS10070 (TOL5_19610) 2181701..2183902 - 2202 WP_100885315.1 glycerol-3-phosphate 1-O-acyltransferase PlsB -
TOL5_RS10075 (TOL5_19620) 2184136..2185134 + 999 WP_042088689.1 cysteine synthase A -
TOL5_RS10080 (TOL5_19630) 2185409..2185915 - 507 WP_121774458.1 AAA family ATPase -
TOL5_RS10085 (TOL5_19640) 2185997..2186269 - 273 WP_058971122.1 NadS family protein Antitoxin
TOL5_RS10090 (TOL5_19650) 2186262..2186582 - 321 WP_121774457.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TOL5_RS10095 (TOL5_19660) 2186967..2187503 - 537 WP_121774456.1 transglycosylase SLT domain-containing protein -
TOL5_RS10100 (TOL5_19670) 2187821..2188183 + 363 WP_227543981.1 hypothetical protein -
TOL5_RS10105 (TOL5_19680) 2188366..2190990 + 2625 WP_121774455.1 type VI secretion system Vgr family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(40-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-75)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12187.02 Da        Isoelectric Point: 7.1644

>T39240 WP_121774457.1 NZ_AP024708:c2186582-2186262 [Acinetobacter sp. Tol 5]
MLFIETSIFTKQIKELVTDDEYRQLQQDLLVEPDKGDVIKNGGGIRKVRCAQGNKAKSGGIRVIYYWVSEDDHIFFLVAY
PKSMKDNLTDKETAILRQLVKEQLHG

Download         Length: 321 bp

>T39240 NZ_AP024708:c2186582-2186262 [Acinetobacter sp. Tol 5]
ATGTTATTTATTGAAACCAGTATTTTTACCAAACAAATCAAAGAACTTGTTACTGATGATGAATATCGCCAGTTACAGCA
AGATCTTTTGGTAGAGCCTGATAAAGGTGATGTGATAAAAAATGGTGGTGGAATACGAAAAGTACGTTGTGCTCAAGGCA
ATAAAGCAAAAAGTGGTGGTATCCGTGTAATCTATTATTGGGTTTCAGAAGATGACCATATTTTCTTTTTAGTGGCTTAT
CCCAAGTCTATGAAAGACAATTTAACGGATAAAGAAACTGCAATTCTACGTCAATTAGTGAAGGAGCAACTTCATGGATA
A

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10135.62 Da        Isoelectric Point: 9.9218

>AT39240 WP_058971122.1 NZ_AP024708:c2186269-2185997 [Acinetobacter sp. Tol 5]
MDNTLFDDLVSSIKEAGAIKRKEIQASRVTELVLPNIKDVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Download         Length: 273 bp

>AT39240 NZ_AP024708:c2186269-2185997 [Acinetobacter sp. Tol 5]
ATGGATAATACTTTATTTGATGACCTCGTTTCTTCGATTAAAGAAGCAGGTGCAATTAAGCGTAAAGAGATTCAGGCAAG
TCGTGTAACAGAACTGGTATTACCTAATATTAAGGACGTACGTGAAAAAACGGGTTTGAGCCAAAATGAATTTGCTGCAC
GCTTGCATATTAGCCCTCGTACTCTACAGAATTGGGAACAAGGTAGACGTTATCCAACAGGCCCAGCAGCGACATTAATT
CGCATTCTAGATGCCCATCCAACTCTGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References