Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4026542..4027130 Replicon chromosome
Accession NZ_AP024684
Organism Stenotrophomonas pavanii strain Y

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag STNY_RS18595 Protein ID WP_080355515.1
Coordinates 4026852..4027130 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8E3RGU6
Locus tag STNY_RS18590 Protein ID WP_049439995.1
Coordinates 4026542..4026841 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STNY_RS18570 (STNY_R36930) 4021969..4023156 + 1188 WP_130768214.1 pyridoxal phosphate-dependent aminotransferase -
STNY_RS18575 (STNY_R36940) 4023281..4025377 - 2097 WP_064239222.1 prolyl oligopeptidase family serine peptidase -
STNY_RS18580 (STNY_R36950) 4025447..4025770 - 324 WP_103282036.1 hypothetical protein -
STNY_RS18585 (STNY_R36960) 4025899..4026501 + 603 WP_049464637.1 lipocalin family protein -
STNY_RS18590 (STNY_R36970) 4026542..4026841 - 300 WP_049439995.1 HigA family addiction module antitoxin Antitoxin
STNY_RS18595 (STNY_R36980) 4026852..4027130 - 279 WP_080355515.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
STNY_RS18600 (STNY_R36990) 4027337..4028026 - 690 WP_103282037.1 methionine ABC transporter permease -
STNY_RS18605 (STNY_R37000) 4028023..4029030 - 1008 WP_010481369.1 methionine ABC transporter ATP-binding protein -
STNY_RS18610 (STNY_R37010) 4029241..4030137 - 897 WP_130768215.1 DMT family transporter -
STNY_RS18615 (STNY_R37020) 4030233..4030715 + 483 WP_049464641.1 YajQ family cyclic di-GMP-binding protein -
STNY_RS18620 (STNY_R37030) 4030750..4031847 - 1098 WP_049464643.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(27-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10682.19 Da        Isoelectric Point: 10.4115

>T39204 WP_080355515.1 NZ_AP024684:c4027130-4026852 [Stenotrophomonas pavanii]
MIRSFRCKQTRALFEGACPRAWRPIRRAAERKLQLLDSAQTLAFLRSPPGNRLEALSGDRRGQYSLRINDQWRLCFTWTD
SGADAVEIVDYH

Download         Length: 279 bp

>T39204 NZ_AP024684:c4027130-4026852 [Stenotrophomonas pavanii]
ATGATCCGTTCATTCCGCTGCAAGCAGACCCGCGCCCTGTTTGAAGGAGCCTGCCCTCGCGCTTGGCGCCCGATACGACG
CGCGGCTGAACGTAAACTCCAGCTGCTCGATTCGGCACAGACGCTGGCCTTCCTGCGCAGCCCGCCCGGGAATCGTCTTG
AGGCGCTGTCAGGTGATCGGAGAGGACAATACAGCCTCCGTATCAATGATCAGTGGCGGCTCTGTTTCACCTGGACCGAC
AGCGGCGCCGATGCCGTGGAAATTGTTGACTATCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10885.59 Da        Isoelectric Point: 11.3450

>AT39204 WP_049439995.1 NZ_AP024684:c4026841-4026542 [Stenotrophomonas pavanii]
MKRPHNGMRAIHPGEILREEFLLPLSLSVNALAKALDVPATRLHAIVHGQRSISADTAARLARHFGGDAASWLAMQAAYD
LKTLPTRSEIERRVQPRAA

Download         Length: 300 bp

>AT39204 NZ_AP024684:c4026841-4026542 [Stenotrophomonas pavanii]
ATGAAGCGTCCCCACAACGGCATGCGCGCCATCCATCCTGGCGAGATCCTGCGCGAAGAGTTTCTGCTGCCCCTGTCGCT
GAGCGTGAATGCGCTGGCGAAGGCGCTGGATGTTCCCGCAACGCGGCTGCACGCCATCGTCCACGGTCAGCGCAGCATCT
CGGCGGACACGGCAGCGCGGTTGGCACGGCATTTCGGCGGGGATGCCGCTTCCTGGCTTGCGATGCAGGCGGCCTACGAT
CTCAAGACATTGCCAACACGCAGCGAGATCGAACGCCGCGTACAGCCTCGGGCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References