Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2943089..2943737 Replicon chromosome
Accession NZ_AP024671
Organism Mycobacterium tuberculosis strain R2092

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag K5645_RS13755 Protein ID WP_003899414.1
Coordinates 2943089..2943412 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag K5645_RS13760 Protein ID WP_003899415.1
Coordinates 2943492..2943737 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5645_RS13725 (MTR2092_27320) 2938412..2939410 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
K5645_RS13730 (MTR2092_27330) 2939424..2939888 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
K5645_RS13735 2939876..2940127 + 252 WP_003908028.1 hypothetical protein -
K5645_RS13740 (MTR2092_27350) 2940298..2941737 - 1440 WP_003901443.1 phage major capsid protein -
K5645_RS13745 (MTR2092_27360) 2941745..2942278 - 534 WP_003899412.1 HK97 family phage prohead protease -
K5645_RS13750 (MTR2092_27370) 2942431..2942922 - 492 WP_003900541.1 phage terminase small subunit P27 family -
K5645_RS13755 (MTR2092_27380) 2943089..2943412 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
K5645_RS13760 (MTR2092_27390) 2943492..2943737 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
K5645_RS13765 (MTR2092_27400) 2943734..2945161 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
K5645_RS13770 (MTR2092_27410) 2945163..2945555 - 393 WP_003899417.1 DUF2742 domain-containing protein -
K5645_RS13775 (MTR2092_27420) 2945552..2945812 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
K5645_RS13780 (MTR2092_27430) 2945829..2946191 - 363 WP_003900543.1 hypothetical protein -
K5645_RS13785 (MTR2092_27440) 2946194..2947321 - 1128 WP_003899420.1 site-specific integrase -
K5645_RS13790 2947466..2947693 - 228 WP_003899421.1 hypothetical protein -
K5645_RS13795 2947690..2948079 - 390 WP_003899422.1 hypothetical protein -
K5645_RS13800 2947985..2948257 + 273 WP_003900544.1 hypothetical protein -
K5645_RS13805 (MTR2092_27460) 2948356..2948589 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2938412..2947321 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T39191 WP_003899414.1 NZ_AP024671:c2943412-2943089 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T39191 NZ_AP024671:c2943412-2943089 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT39191 WP_003899415.1 NZ_AP024671:c2943737-2943492 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT39191 NZ_AP024671:c2943737-2943492 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References