Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4196080..4196896 Replicon chromosome
Accession NZ_AP024585
Organism Citrobacter amalonaticus strain JCM 1661

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag KI228_RS19890 Protein ID WP_061069544.1
Coordinates 4196080..4196556 (-) Length 159 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A3Q8DNJ3
Locus tag KI228_RS19895 Protein ID WP_042999108.1
Coordinates 4196561..4196896 (-) Length 112 a.a.

Genomic Context

KI228_RS19870KI228_RS19875KI228_RS19880KI228_RS19885KI228_RS19890KI228_RS19895KI228_RS19900KI228_RS19905KI228_RS19910KI228_RS19915
Location: 4191185..4191928 (744 bp)
Type: Others
Protein ID: WP_044264050.1
Location: 4191971..4194415 (2445 bp)
Type: Others
Protein ID: WP_224267598.1
Location: 4194509..4195057 (549 bp)
Type: Others
Protein ID: WP_042999111.1
Location: 4195126..4195656 (531 bp)
Type: Others
Protein ID: WP_042999110.1
Location: 4196080..4196556 (477 bp)
Type: Toxin
Protein ID: WP_061069544.1
Location: 4196561..4196896 (336 bp)
Type: Antitoxin
Protein ID: WP_042999108.1
Location: 4197111..4197647 (537 bp)
Type: Others
Protein ID: WP_042999107.1
Location: 4197644..4198240 (597 bp)
Type: Others
Protein ID: WP_042999106.1
Location: 4198285..4199058 (774 bp)
Type: Others
Protein ID: WP_044257303.1
Location: 4199051..4199677 (627 bp)
Type: Others
Protein ID: WP_042999104.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KI228_RS19870 (CIAM_38930)4191185..4191928-744WP_044264050.1molecular chaperone-
KI228_RS19875 (CIAM_38940)4191971..4194415-2445WP_224267598.1fimbria/pilus outer membrane usher protein-
KI228_RS19880 (CIAM_38950)4194509..4195057-549WP_042999111.1fimbrial protein-
KI228_RS19885 (CIAM_38960)4195126..4195656-531WP_042999110.1fimbrial protein-
KI228_RS19890 (CIAM_38970)4196080..4196556-477WP_061069544.1type II toxin-antitoxin system YhaV family toxinToxin
KI228_RS19895 (CIAM_38980)4196561..4196896-336WP_042999108.1type II toxin-antitoxin system PrlF family antitoxinAntitoxin
KI228_RS19900 (CIAM_38990)4197111..4197647-537WP_042999107.1ferredoxin-type protein NapF-
KI228_RS19905 (CIAM_39000)4197644..4198240-597WP_042999106.1molecular chaperone-
KI228_RS19910 (CIAM_39010)4198285..4199058-774WP_044257303.1dimethyl sulfoxide reductase anchor subunit-
KI228_RS19915 (CIAM_39020)4199051..4199677-627WP_042999104.1dimethylsulfoxide reductase subunit B-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(15-110)


Sequences

Toxin        


Download         Length: 159 a.a.        Molecular weight: 18194.81 Da        Isoelectric Point: 8.4404

>T38876 WP_061069544.1 NZ_AP024585:c4196556-4196080 [Citrobacter amalonaticus]
MDFPTWLNGWTIYAHPCFIDQYNALVARVEDLKHRFPDPIVFQKKKETKVLAHLLKSIANITHEPRASVYLPGDSIGKAY
TDWSRAKFGGGRYRLFFRYSLESKIIVIAWVNDEGPLRTYGSKTDAYKIFGKMLDEGNPPDDWLSLLQACQNDGKEHL

Download         Length: 477 bp

>T38876 NZ_AP024585:c4196556-4196080 [Citrobacter amalonaticus]
ATGGATTTTCCCACATGGCTGAACGGGTGGACGATCTACGCTCATCCCTGTTTTATCGATCAATACAACGCGCTGGTCGC
ACGTGTTGAAGACCTTAAGCACAGGTTTCCAGATCCCATTGTTTTCCAGAAGAAGAAAGAGACCAAGGTGCTGGCGCATT
TATTGAAATCCATTGCCAACATTACCCACGAACCCCGAGCTTCTGTTTACCTGCCTGGTGACAGTATAGGGAAAGCTTAT
ACAGACTGGTCGAGAGCGAAGTTTGGTGGGGGACGGTATCGCTTATTTTTCCGTTATAGTCTCGAGAGTAAGATCATTGT
CATCGCATGGGTGAATGATGAAGGGCCATTGCGCACCTACGGCAGCAAGACCGATGCCTATAAGATTTTCGGGAAAATGC
TCGATGAGGGGAATCCACCCGACGACTGGCTAAGTTTGCTTCAGGCTTGTCAAAACGACGGGAAGGAACATCTTTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12505.83 Da        Isoelectric Point: 4.1876

>AT38876 WP_042999108.1 NZ_AP024585:c4196896-4196561 [Citrobacter amalonaticus]
MFAYVRSEDIAIEADSKLTERHQTTIPASIRDALHLRSGDRIHYTLLSTGEVLLSKYSEATEDGVMRSFLDFLSQDVANN
PQTLKKLDLSRGYELVDGIDVNLDDEISDED

Download         Length: 336 bp

>AT38876 NZ_AP024585:c4196896-4196561 [Citrobacter amalonaticus]
ATGTTCGCCTATGTTCGATCTGAAGACATTGCCATTGAAGCGGATTCTAAATTGACGGAACGACATCAAACGACTATCCC
TGCGTCGATCAGGGACGCTTTACATCTTCGCAGTGGTGATCGTATTCATTACACATTGCTTTCCACGGGTGAAGTACTGC
TTTCAAAATACAGTGAAGCAACGGAGGACGGTGTGATGCGATCATTCCTGGACTTCTTATCACAGGATGTGGCGAATAAC
CCACAAACGCTGAAGAAGCTGGATTTATCCCGTGGCTATGAACTGGTTGATGGTATCGACGTCAATCTTGATGATGAAAT
CAGCGACGAAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3Q8DNJ3

References