Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 1517000..1517605 | Replicon | chromosome |
| Accession | NZ_AP024565 | ||
| Organism | Microcystis aeruginosa strain NIES-88 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | I4FMI0 |
| Locus tag | LC603172_RS07355 | Protein ID | WP_002740810.1 |
| Coordinates | 1517324..1517605 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LC603172_RS07350 | Protein ID | WP_036399402.1 |
| Coordinates | 1517000..1517314 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LC603172_RS07330 | 1512217..1512438 | + | 222 | WP_221275582.1 | hypothetical protein | - |
| LC603172_RS07335 (MAN88_14240) | 1512532..1516104 | - | 3573 | WP_061431375.1 | DUF3110 domain-containing protein | - |
| LC603172_RS07340 (MAN88_14250) | 1516305..1516451 | - | 147 | WP_072319654.1 | type II toxin-antitoxin system HicA family toxin | - |
| LC603172_RS07345 (MAN88_14260) | 1516441..1516647 | - | 207 | WP_002740815.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| LC603172_RS07350 (MAN88_14280) | 1517000..1517314 | - | 315 | WP_036399402.1 | HigA family addiction module antitoxin | Antitoxin |
| LC603172_RS07355 (MAN88_14290) | 1517324..1517605 | - | 282 | WP_002740810.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LC603172_RS07360 (MAN88_14300) | 1517905..1518063 | - | 159 | WP_192845989.1 | hypothetical protein | - |
| LC603172_RS07365 (MAN88_14310) | 1518182..1518394 | - | 213 | WP_002759169.1 | type II toxin-antitoxin system HicA family toxin | - |
| LC603172_RS07370 | 1518387..1518593 | - | 207 | WP_012264985.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| LC603172_RS07380 (MAN88_14330) | 1519117..1519377 | + | 261 | WP_041803907.1 | hypothetical protein | - |
| LC603172_RS07385 (MAN88_14340) | 1519364..1519786 | + | 423 | WP_061431374.1 | type II toxin-antitoxin system VapC family toxin | - |
| LC603172_RS07390 (MAN88_14350) | 1519858..1520205 | - | 348 | WP_002751511.1 | hypothetical protein | - |
| LC603172_RS07395 (MAN88_14360) | 1520242..1520388 | - | 147 | WP_155726632.1 | hypothetical protein | - |
| LC603172_RS07400 (MAN88_14370) | 1520495..1520710 | + | 216 | WP_061431373.1 | hypothetical protein | - |
| LC603172_RS07405 (MAN88_14380) | 1520757..1520981 | + | 225 | WP_239698044.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LC603172_RS07410 (MAN88_14390) | 1521228..1521452 | + | 225 | WP_239698043.1 | hypothetical protein | - |
| LC603172_RS07415 (MAN88_14400) | 1521584..1521865 | - | 282 | WP_002736843.1 | hemolysin XhlA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1510889..1512103 | 1214 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11127.76 Da Isoelectric Point: 9.7184
>T38755 WP_002740810.1 NZ_AP024565:c1517605-1517324 [Microcystis aeruginosa]
VIQNFKDKEAQKVFERKHSRKLPLDIQQVALRKLRMLNRAETLQDLRVPPANRLERLVGDREGQYSIRVNDQWRICFVWQ
NGDALDVEIVDYH
VIQNFKDKEAQKVFERKHSRKLPLDIQQVALRKLRMLNRAETLQDLRVPPANRLERLVGDREGQYSIRVNDQWRICFVWQ
NGDALDVEIVDYH
Download Length: 282 bp
>T38755 NZ_AP024565:c1517605-1517324 [Microcystis aeruginosa]
GTGATCCAAAACTTTAAAGATAAAGAAGCTCAAAAAGTTTTTGAACGTAAACATTCGCGTAAATTGCCATTAGATATCCA
ACAAGTGGCATTGCGAAAATTGCGGATGCTTAATCGTGCGGAAACCCTGCAAGATCTTCGTGTCCCACCAGCAAATCGAT
TGGAACGTCTGGTTGGTGACAGGGAAGGTCAATATAGCATTCGGGTTAACGATCAATGGCGAATTTGCTTTGTCTGGCAA
AACGGTGATGCTCTAGACGTAGAAATCGTTGATTATCATTGA
GTGATCCAAAACTTTAAAGATAAAGAAGCTCAAAAAGTTTTTGAACGTAAACATTCGCGTAAATTGCCATTAGATATCCA
ACAAGTGGCATTGCGAAAATTGCGGATGCTTAATCGTGCGGAAACCCTGCAAGATCTTCGTGTCCCACCAGCAAATCGAT
TGGAACGTCTGGTTGGTGACAGGGAAGGTCAATATAGCATTCGGGTTAACGATCAATGGCGAATTTGCTTTGTCTGGCAA
AACGGTGATGCTCTAGACGTAGAAATCGTTGATTATCATTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11812.70 Da Isoelectric Point: 4.0742
>AT38755 WP_036399402.1 NZ_AP024565:c1517314-1517000 [Microcystis aeruginosa]
MNEDKLMPIHPGEVLLEEFIKPMNLSQNQIALALGVPEQCINEIVHGKQPITADIALRLARYFDMSPRFWLGLQMDYDLD
VVEDEIGDQLDKEVAVMTVICAEK
MNEDKLMPIHPGEVLLEEFIKPMNLSQNQIALALGVPEQCINEIVHGKQPITADIALRLARYFDMSPRFWLGLQMDYDLD
VVEDEIGDQLDKEVAVMTVICAEK
Download Length: 315 bp
>AT38755 NZ_AP024565:c1517314-1517000 [Microcystis aeruginosa]
ATGAATGAAGATAAACTAATGCCAATTCATCCCGGTGAGGTTCTTTTAGAGGAATTTATCAAGCCAATGAACCTTAGTCA
GAATCAAATAGCTCTGGCTCTTGGAGTTCCTGAACAATGTATTAACGAAATCGTTCACGGAAAGCAGCCTATCACGGCGG
ATATAGCTCTTCGGTTAGCTCGTTATTTTGATATGTCACCGCGATTTTGGCTGGGATTACAAATGGATTACGATCTGGAC
GTTGTTGAAGATGAAATAGGAGATCAATTGGACAAAGAAGTTGCTGTAATGACAGTTATTTGTGCAGAAAAGTAA
ATGAATGAAGATAAACTAATGCCAATTCATCCCGGTGAGGTTCTTTTAGAGGAATTTATCAAGCCAATGAACCTTAGTCA
GAATCAAATAGCTCTGGCTCTTGGAGTTCCTGAACAATGTATTAACGAAATCGTTCACGGAAAGCAGCCTATCACGGCGG
ATATAGCTCTTCGGTTAGCTCGTTATTTTGATATGTCACCGCGATTTTGGCTGGGATTACAAATGGATTACGATCTGGAC
GTTGTTGAAGATGAAATAGGAGATCAATTGGACAAAGAAGTTGCTGTAATGACAGTTATTTGTGCAGAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|