Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1761289..1761982 Replicon chromosome
Accession NZ_AP024560
Organism Escherichia coli strain NIPH17_0020

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag FLY91_RS08435 Protein ID WP_000415585.1
Coordinates 1761289..1761585 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag FLY91_RS08440 Protein ID WP_000650107.1
Coordinates 1761587..1761982 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FLY91_RS08405 (1756752) 1756752..1757231 + 480 WP_000065332.1 Hcp family type VI secretion system effector -
FLY91_RS08410 (1757234) 1757234..1757656 + 423 Protein_1656 hypothetical protein -
FLY91_RS08415 (1758000) 1758000..1759349 - 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
FLY91_RS08420 (1759346) 1759346..1760005 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
FLY91_RS08425 (1760157) 1760157..1760549 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
FLY91_RS08430 (1760602) 1760602..1761084 + 483 WP_000183505.1 GyrI-like domain-containing protein -
FLY91_RS08435 (1761289) 1761289..1761585 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
FLY91_RS08440 (1761587) 1761587..1761982 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
FLY91_RS08445 (1762115) 1762115..1763722 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
FLY91_RS08450 (1763860) 1763860..1766118 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T38706 WP_000415585.1 NZ_AP024560:1761289-1761585 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T38706 NZ_AP024560:1761289-1761585 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT38706 WP_000650107.1 NZ_AP024560:1761587-1761982 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT38706 NZ_AP024560:1761587-1761982 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References