Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 714478..715093 | Replicon | chromosome |
| Accession | NZ_AP024552 | ||
| Organism | Vibrio cholerae strain IDH-02387 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMG5 |
| Locus tag | K6J81_RS17440 | Protein ID | WP_001162670.1 |
| Coordinates | 714806..715093 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | K6J81_RS17435 | Protein ID | WP_001232701.1 |
| Coordinates | 714478..714795 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6J81_RS17400 | 709887..710348 | - | 462 | WP_001911752.1 | lipocalin family protein | - |
| K6J81_RS17405 | 710539..711015 | - | 477 | WP_001047180.1 | GNAT family N-acetyltransferase | - |
| K6J81_RS19275 | 711043..711153 | - | 111 | WP_071917832.1 | DUF3265 domain-containing protein | - |
| K6J81_RS17410 | 711150..712079 | - | 930 | WP_000335802.1 | hypothetical protein | - |
| K6J81_RS17415 | 712199..712645 | - | 447 | WP_000128977.1 | hypothetical protein | - |
| K6J81_RS17420 | 712798..713802 | - | 1005 | WP_000964925.1 | LD-carboxypeptidase | - |
| K6J81_RS19280 | 713990..714106 | - | 117 | WP_001889170.1 | hypothetical protein | - |
| K6J81_RS17430 | 714069..714194 | - | 126 | WP_001944767.1 | DUF645 family protein | - |
| K6J81_RS19285 | 714222..714332 | - | 111 | Protein_654 | acetyltransferase | - |
| K6J81_RS19290 | 714371..714481 | - | 111 | WP_134814058.1 | DUF3265 domain-containing protein | - |
| K6J81_RS17435 | 714478..714795 | - | 318 | WP_001232701.1 | HigA family addiction module antitoxin | Antitoxin |
| K6J81_RS17440 | 714806..715093 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K6J81_RS19295 | 715134..715247 | - | 114 | WP_001894955.1 | hypothetical protein | - |
| K6J81_RS17445 | 715360..715540 | - | 181 | Protein_659 | DUF645 family protein | - |
| K6J81_RS17450 | 715965..716198 | - | 234 | WP_032482776.1 | DUF3709 domain-containing protein | - |
| K6J81_RS19300 | 716219..716412 | - | 194 | Protein_661 | hypothetical protein | - |
| K6J81_RS17455 | 716601..716819 | - | 219 | WP_001917086.1 | DUF3709 domain-containing protein | - |
| K6J81_RS19305 | 716831..717040 | - | 210 | WP_001900246.1 | DUF3709 domain-containing protein | - |
| K6J81_RS17460 | 717129..717782 | - | 654 | WP_000226874.1 | hypothetical protein | - |
| K6J81_RS17465 | 717839..718348 | - | 510 | WP_000405987.1 | GNAT family N-acetyltransferase | - |
| K6J81_RS17470 | 718590..718832 | + | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| K6J81_RS17475 | 718851..719168 | + | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| K6J81_RS19310 | 719362..719514 | - | 153 | Protein_668 | DUF645 family protein | - |
| K6J81_RS19315 | 719575..719750 | - | 176 | Protein_669 | acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 672778..725906 | 53128 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T38658 WP_001162670.1 NZ_AP024552:c715093-714806 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T38658 NZ_AP024552:c715093-714806 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11705.63 Da Isoelectric Point: 10.4711
>AT38658 WP_001232701.1 NZ_AP024552:c714795-714478 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT38658 NZ_AP024552:c714795-714478 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|