Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2477449..2477966 | Replicon | chromosome |
| Accession | NZ_AP024511 | ||
| Organism | Staphylococcus aureus isolate 2007-13 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | KJS82_RS12195 | Protein ID | WP_000113265.1 |
| Coordinates | 2477700..2477966 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | KJS82_RS12190 | Protein ID | WP_000584499.1 |
| Coordinates | 2477449..2477700 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KJS82_RS12160 (2473147) | 2473147..2473866 | + | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
| KJS82_RS12165 (2473863) | 2473863..2474594 | + | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| KJS82_RS12170 (2474691) | 2474691..2475941 | - | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
| KJS82_RS12175 (2476196) | 2476196..2476558 | + | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| KJS82_RS12180 (2476577) | 2476577..2477176 | + | 600 | WP_000162810.1 | DsbA family protein | - |
| KJS82_RS12185 (2477204) | 2477204..2477284 | + | 81 | WP_223197974.1 | hypothetical protein | - |
| KJS82_RS12190 (2477449) | 2477449..2477700 | + | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KJS82_RS12195 (2477700) | 2477700..2477966 | + | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| KJS82_RS12200 (2478001) | 2478001..2478072 | + | 72 | Protein_2384 | hypothetical protein | - |
| KJS82_RS12205 (2478261) | 2478261..2479808 | + | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| KJS82_RS12210 (2479994) | 2479994..2480461 | + | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| KJS82_RS12215 (2480545) | 2480545..2480727 | + | 183 | WP_000230292.1 | hypothetical protein | - |
| KJS82_RS12220 (2480944) | 2480944..2481768 | + | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| KJS82_RS12225 (2482002) | 2482002..2482538 | + | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T38532 WP_000113265.1 NZ_AP024511:2477700-2477966 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T38532 NZ_AP024511:2477700-2477966 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT38532 WP_000584499.1 NZ_AP024511:2477449-2477700 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT38532 NZ_AP024511:2477449-2477700 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|