Detailed information of TA system TA038524

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 548746..549325
• Replicon: chromosome
• Accession: NZ_AP024511
• Organism: Staphylococcus aureus isolate 2007-13

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: KJS82_RS03045
• Protein ID: WP_001025401.1
• Coordinates: 548746..548991 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	548960..549325 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJS82_RS03000 (544764)	544764..545378	+	615	WP_000191459.1	hypothetical protein	-
KJS82_RS03005 (545375)	545375..545521	-	147	WP_001013104.1	hypothetical protein	-
KJS82_RS03010 (545751)	545751..546335	-	585	WP_000825948.1	hypothetical protein	-
KJS82_RS03015 (546353)	546353..546814	-	462	WP_000525004.1	hypothetical protein	-
KJS82_RS03020 (546827)	546827..547141	-	315	WP_000333630.1	helix-turn-helix transcriptional regulator	-
KJS82_RS03025 (547293)	547293..547529	+	237	WP_001121027.1	helix-turn-helix transcriptional regulator	-
KJS82_RS03030 (547543)	547543..548319	+	777	WP_001148544.1	Rha family transcriptional regulator	-
KJS82_RS03035 (548348)	548348..548491	+	144	WP_000939498.1	hypothetical protein	-
KJS82_RS03040 (548481)	548481..548690	-	210	WP_000642492.1	hypothetical protein	-
KJS82_RS03045 (548746)	548746..548991	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
KJS82_RS03050 (548960)	548960..549325	-	366	WP_001128433.1	hypothetical protein	Antitoxin
KJS82_RS03055 (549380)	549380..549595	+	216	WP_001097552.1	hypothetical protein	-
KJS82_RS03060 (549620)	549620..549883	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
KJS82_RS03065 (549896)	549896..550057	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
KJS82_RS03070 (550136)	550136..550459	+	324	WP_000174998.1	hypothetical protein	-
KJS82_RS03075 (550474)	550474..550836	+	363	WP_000985984.1	hypothetical protein	-
KJS82_RS03080 (550833)	550833..551999	+	1167	WP_000762547.1	DUF2800 domain-containing protein	-
KJS82_RS03085 (552025)	552025..552582	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T38524 WP_001025401.1 NZ_AP024511:548746-548991 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T38524 NZ_AP024511:548746-548991 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT38524 NZ_AP024511:c549325-548960 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin