Detailed information of TA system TA038517

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 18803..19142
• Replicon: chromosome
• Accession: NZ_AP024511
• Organism: Staphylococcus aureus isolate 2007-13

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KJS82_RS00100
• Protein ID: WP_011447039.1
• Coordinates: 18803..18979 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	18967..19142 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJS82_RS00080	14038..17823	+	3786	WP_000582165.1	phage tail spike protein	-
KJS82_RS00085	17813..17965	+	153	WP_001153681.1	hypothetical protein	-
KJS82_RS00090	18012..18299	+	288	WP_001040261.1	hypothetical protein	-
KJS82_RS00095	18357..18653	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
KJS82_RS00100	18803..18979	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	18967..19142	-	176	-	-	Antitoxin
KJS82_RS00110	19192..19446	+	255	WP_000611512.1	phage holin	-
KJS82_RS00115	19458..20213	+	756	WP_000861038.1	CHAP domain-containing protein	-
KJS82_RS00120	20404..20895	+	492	WP_000920038.1	staphylokinase	-
KJS82_RS00125	21546..21881	+	336	Protein_25	SH3 domain-containing protein	-
KJS82_RS00130	22392..22742	+	351	WP_031906254.1	complement inhibitor SCIN-A	-
KJS82_RS00135	22795..23055	-	261	WP_001791826.1	hypothetical protein	-
KJS82_RS00140	23366..23545	-	180	WP_000669791.1	hypothetical protein	-
KJS82_RS00145	23917..24114	-	198	WP_000239610.1	phospholipase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / scn	1..22742	22741

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T38517 WP_011447039.1 NZ_AP024511:18803-18979 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T38517 NZ_AP024511:18803-18979 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 176 bp

>AT38517 NZ_AP024511:c19142-18967 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGA
TGGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin