Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 3093390..3094662 Replicon chromosome
Accession NZ_AP024484
Organism Prevotella sp. WR041

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag prwr041_RS11815 Protein ID WP_207153959.1
Coordinates 3093721..3094662 (+) Length 314 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag prwr041_RS11810 Protein ID WP_207153958.1
Coordinates 3093390..3093728 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
prwr041_RS11785 3088669..3089089 - 421 Protein_2284 transposase -
prwr041_RS11790 3089099..3089827 - 729 WP_207153954.1 6-phosphogluconolactonase -
prwr041_RS11795 3089808..3091295 - 1488 WP_207153955.1 glucose-6-phosphate dehydrogenase -
prwr041_RS11800 3091319..3092788 - 1470 WP_207153956.1 decarboxylating NADP(+)-dependent phosphogluconate dehydrogenase -
prwr041_RS11805 3093181..3093387 + 207 WP_207153957.1 type II toxin-antitoxin system Y4mF family antitoxin -
prwr041_RS11810 3093390..3093728 + 339 WP_207153958.1 HipA N-terminal domain-containing protein Antitoxin
prwr041_RS11815 3093721..3094662 + 942 WP_207153959.1 HipA domain-containing protein Toxin
prwr041_RS11820 3094936..3095232 + 297 WP_207153960.1 thioredoxin -
prwr041_RS11825 3095238..3095501 + 264 WP_207153961.1 GlsB/YeaQ/YmgE family stress response membrane protein -
prwr041_RS11830 3095630..3096034 + 405 WP_207153962.1 translation initiation factor -
prwr041_RS11835 3096036..3096422 + 387 WP_207153963.1 VOC family protein -
prwr041_RS11840 3096419..3097453 + 1035 WP_207153964.1 winged helix DNA-binding domain-containing protein -
prwr041_RS11845 3097465..3097821 + 357 WP_207153966.1 MmcQ/YjbR family DNA-binding protein -
prwr041_RS11850 3097874..3098812 - 939 WP_207153967.1 nitronate monooxygenase -
prwr041_RS11855 3098870..3099487 - 618 WP_207155680.1 HAD-IA family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(54-277)

Antitoxin

HipA, N-terminal subdomain 1

(4-101)


Sequences

Toxin        


Download         Length: 314 a.a.        Molecular weight: 36083.81 Da        Isoelectric Point: 6.4961

>T38472 WP_207153959.1 NZ_AP024484:3093721-3094662 [Prevotella sp. WR041]
MCKCLYCYGTLAKEEKDMHPACAKKFFGTTVIPTLDYTTEHLEELAKQVIQGQTSLTGVQSKLSLNLNEHEGSKRLTIVG
LWGGYICKPQTIAYEQMPEVEDLTMHLAELARIKVVPHTLMRMADNSLCYLTRRIDRTSNGEKLAMEDMCQLTERQTEHK
YKSSYERIGKALLHYSTVPKMDVTNFFEMVLFSWLTGNNDMHLKNFSLYEPQDGVIRLTPAYDLLNVAIINPNDDEELAL
TLNGRKKKLAKENFLKCAESLGIETIVVDRLINKYVKLLPKFENMINNSFLDEELQRKFSELLKERLDRLILE

Download         Length: 942 bp

>T38472 NZ_AP024484:3093721-3094662 [Prevotella sp. WR041]
ATGTGTAAATGTTTGTATTGCTATGGTACACTTGCAAAAGAGGAAAAGGACATGCATCCTGCTTGTGCGAAAAAGTTTTT
CGGCACAACGGTTATACCAACTTTGGATTATACAACCGAGCATTTGGAAGAACTTGCTAAGCAGGTGATACAAGGTCAGA
CTTCGCTTACTGGTGTTCAATCTAAATTGTCTTTGAACTTGAATGAACATGAGGGAAGCAAGCGGCTTACAATAGTGGGC
TTATGGGGAGGCTATATCTGTAAACCACAGACAATTGCCTATGAGCAAATGCCAGAAGTTGAAGATTTGACAATGCATCT
GGCTGAGTTGGCTCGTATTAAAGTCGTGCCTCATACTCTGATGCGTATGGCTGACAATTCGCTCTGTTATCTTACGCGTC
GTATAGACCGAACTTCAAATGGTGAAAAGTTGGCAATGGAAGATATGTGTCAACTTACCGAGAGACAAACCGAACATAAG
TATAAAAGTAGTTACGAGCGTATAGGAAAAGCGTTACTTCATTATTCTACTGTTCCCAAGATGGATGTTACTAATTTCTT
TGAAATGGTCTTGTTTTCATGGTTGACAGGTAATAACGATATGCACCTGAAAAACTTTTCACTCTATGAGCCCCAAGATG
GTGTTATCCGCTTAACCCCTGCCTATGATTTGCTAAATGTAGCTATTATTAATCCTAATGATGACGAAGAGCTGGCTTTG
ACATTGAATGGGCGAAAGAAAAAGTTGGCGAAAGAAAACTTTCTGAAATGTGCTGAAAGTCTAGGTATTGAAACTATCGT
TGTGGATCGTCTTATCAATAAATATGTTAAGCTTCTGCCGAAGTTTGAAAATATGATTAATAACTCATTCTTGGATGAAG
AACTGCAAAGGAAATTTTCAGAGTTACTAAAAGAAAGACTTGATAGGCTTATTTTGGAATAG

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12442.43 Da        Isoelectric Point: 4.0177

>AT38472 WP_207153958.1 NZ_AP024484:3093390-3093728 [Prevotella sp. WR041]
MKQANVYYKSQLAGVLTENDEGYEFCYLPAYLSSGSAKPVSLTLPLQEDIFKSSVLFPFFDGLIPEGWLLDIAIRDMDIS
ILDRMSLLLLCCKDCIGAVSIEPIQGKEVDNV

Download         Length: 339 bp

>AT38472 NZ_AP024484:3093390-3093728 [Prevotella sp. WR041]
ATGAAACAAGCCAATGTTTATTATAAAAGTCAATTAGCCGGAGTATTGACAGAAAACGATGAAGGTTATGAATTTTGTTA
TCTTCCAGCCTATCTGTCGTCAGGAAGTGCTAAGCCTGTAAGTTTAACATTGCCATTGCAGGAAGATATATTTAAAAGTA
GCGTATTGTTTCCATTTTTCGATGGACTTATACCAGAAGGATGGCTGCTCGATATTGCTATTCGCGATATGGATATCAGT
ATTCTTGATCGTATGTCTCTACTATTGCTATGTTGCAAGGACTGTATCGGGGCGGTAAGTATTGAACCTATTCAAGGAAA
GGAGGTAGACAATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References