Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
Location | 3093390..3094662 | Replicon | chromosome |
Accession | NZ_AP024484 | ||
Organism | Prevotella sp. WR041 |
Toxin (Protein)
Gene name | HipT | Uniprot ID | - |
Locus tag | prwr041_RS11815 | Protein ID | WP_207153959.1 |
Coordinates | 3093721..3094662 (+) | Length | 314 a.a. |
Antitoxin (Protein)
Gene name | HipS | Uniprot ID | - |
Locus tag | prwr041_RS11810 | Protein ID | WP_207153958.1 |
Coordinates | 3093390..3093728 (+) | Length | 113 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
prwr041_RS11785 | 3088669..3089089 | - | 421 | Protein_2284 | transposase | - |
prwr041_RS11790 | 3089099..3089827 | - | 729 | WP_207153954.1 | 6-phosphogluconolactonase | - |
prwr041_RS11795 | 3089808..3091295 | - | 1488 | WP_207153955.1 | glucose-6-phosphate dehydrogenase | - |
prwr041_RS11800 | 3091319..3092788 | - | 1470 | WP_207153956.1 | decarboxylating NADP(+)-dependent phosphogluconate dehydrogenase | - |
prwr041_RS11805 | 3093181..3093387 | + | 207 | WP_207153957.1 | type II toxin-antitoxin system Y4mF family antitoxin | - |
prwr041_RS11810 | 3093390..3093728 | + | 339 | WP_207153958.1 | HipA N-terminal domain-containing protein | Antitoxin |
prwr041_RS11815 | 3093721..3094662 | + | 942 | WP_207153959.1 | HipA domain-containing protein | Toxin |
prwr041_RS11820 | 3094936..3095232 | + | 297 | WP_207153960.1 | thioredoxin | - |
prwr041_RS11825 | 3095238..3095501 | + | 264 | WP_207153961.1 | GlsB/YeaQ/YmgE family stress response membrane protein | - |
prwr041_RS11830 | 3095630..3096034 | + | 405 | WP_207153962.1 | translation initiation factor | - |
prwr041_RS11835 | 3096036..3096422 | + | 387 | WP_207153963.1 | VOC family protein | - |
prwr041_RS11840 | 3096419..3097453 | + | 1035 | WP_207153964.1 | winged helix DNA-binding domain-containing protein | - |
prwr041_RS11845 | 3097465..3097821 | + | 357 | WP_207153966.1 | MmcQ/YjbR family DNA-binding protein | - |
prwr041_RS11850 | 3097874..3098812 | - | 939 | WP_207153967.1 | nitronate monooxygenase | - |
prwr041_RS11855 | 3098870..3099487 | - | 618 | WP_207155680.1 | HAD-IA family hydrolase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 314 a.a. Molecular weight: 36083.81 Da Isoelectric Point: 6.4961
>T38472 WP_207153959.1 NZ_AP024484:3093721-3094662 [Prevotella sp. WR041]
MCKCLYCYGTLAKEEKDMHPACAKKFFGTTVIPTLDYTTEHLEELAKQVIQGQTSLTGVQSKLSLNLNEHEGSKRLTIVG
LWGGYICKPQTIAYEQMPEVEDLTMHLAELARIKVVPHTLMRMADNSLCYLTRRIDRTSNGEKLAMEDMCQLTERQTEHK
YKSSYERIGKALLHYSTVPKMDVTNFFEMVLFSWLTGNNDMHLKNFSLYEPQDGVIRLTPAYDLLNVAIINPNDDEELAL
TLNGRKKKLAKENFLKCAESLGIETIVVDRLINKYVKLLPKFENMINNSFLDEELQRKFSELLKERLDRLILE
MCKCLYCYGTLAKEEKDMHPACAKKFFGTTVIPTLDYTTEHLEELAKQVIQGQTSLTGVQSKLSLNLNEHEGSKRLTIVG
LWGGYICKPQTIAYEQMPEVEDLTMHLAELARIKVVPHTLMRMADNSLCYLTRRIDRTSNGEKLAMEDMCQLTERQTEHK
YKSSYERIGKALLHYSTVPKMDVTNFFEMVLFSWLTGNNDMHLKNFSLYEPQDGVIRLTPAYDLLNVAIINPNDDEELAL
TLNGRKKKLAKENFLKCAESLGIETIVVDRLINKYVKLLPKFENMINNSFLDEELQRKFSELLKERLDRLILE
Download Length: 942 bp
>T38472 NZ_AP024484:3093721-3094662 [Prevotella sp. WR041]
ATGTGTAAATGTTTGTATTGCTATGGTACACTTGCAAAAGAGGAAAAGGACATGCATCCTGCTTGTGCGAAAAAGTTTTT
CGGCACAACGGTTATACCAACTTTGGATTATACAACCGAGCATTTGGAAGAACTTGCTAAGCAGGTGATACAAGGTCAGA
CTTCGCTTACTGGTGTTCAATCTAAATTGTCTTTGAACTTGAATGAACATGAGGGAAGCAAGCGGCTTACAATAGTGGGC
TTATGGGGAGGCTATATCTGTAAACCACAGACAATTGCCTATGAGCAAATGCCAGAAGTTGAAGATTTGACAATGCATCT
GGCTGAGTTGGCTCGTATTAAAGTCGTGCCTCATACTCTGATGCGTATGGCTGACAATTCGCTCTGTTATCTTACGCGTC
GTATAGACCGAACTTCAAATGGTGAAAAGTTGGCAATGGAAGATATGTGTCAACTTACCGAGAGACAAACCGAACATAAG
TATAAAAGTAGTTACGAGCGTATAGGAAAAGCGTTACTTCATTATTCTACTGTTCCCAAGATGGATGTTACTAATTTCTT
TGAAATGGTCTTGTTTTCATGGTTGACAGGTAATAACGATATGCACCTGAAAAACTTTTCACTCTATGAGCCCCAAGATG
GTGTTATCCGCTTAACCCCTGCCTATGATTTGCTAAATGTAGCTATTATTAATCCTAATGATGACGAAGAGCTGGCTTTG
ACATTGAATGGGCGAAAGAAAAAGTTGGCGAAAGAAAACTTTCTGAAATGTGCTGAAAGTCTAGGTATTGAAACTATCGT
TGTGGATCGTCTTATCAATAAATATGTTAAGCTTCTGCCGAAGTTTGAAAATATGATTAATAACTCATTCTTGGATGAAG
AACTGCAAAGGAAATTTTCAGAGTTACTAAAAGAAAGACTTGATAGGCTTATTTTGGAATAG
ATGTGTAAATGTTTGTATTGCTATGGTACACTTGCAAAAGAGGAAAAGGACATGCATCCTGCTTGTGCGAAAAAGTTTTT
CGGCACAACGGTTATACCAACTTTGGATTATACAACCGAGCATTTGGAAGAACTTGCTAAGCAGGTGATACAAGGTCAGA
CTTCGCTTACTGGTGTTCAATCTAAATTGTCTTTGAACTTGAATGAACATGAGGGAAGCAAGCGGCTTACAATAGTGGGC
TTATGGGGAGGCTATATCTGTAAACCACAGACAATTGCCTATGAGCAAATGCCAGAAGTTGAAGATTTGACAATGCATCT
GGCTGAGTTGGCTCGTATTAAAGTCGTGCCTCATACTCTGATGCGTATGGCTGACAATTCGCTCTGTTATCTTACGCGTC
GTATAGACCGAACTTCAAATGGTGAAAAGTTGGCAATGGAAGATATGTGTCAACTTACCGAGAGACAAACCGAACATAAG
TATAAAAGTAGTTACGAGCGTATAGGAAAAGCGTTACTTCATTATTCTACTGTTCCCAAGATGGATGTTACTAATTTCTT
TGAAATGGTCTTGTTTTCATGGTTGACAGGTAATAACGATATGCACCTGAAAAACTTTTCACTCTATGAGCCCCAAGATG
GTGTTATCCGCTTAACCCCTGCCTATGATTTGCTAAATGTAGCTATTATTAATCCTAATGATGACGAAGAGCTGGCTTTG
ACATTGAATGGGCGAAAGAAAAAGTTGGCGAAAGAAAACTTTCTGAAATGTGCTGAAAGTCTAGGTATTGAAACTATCGT
TGTGGATCGTCTTATCAATAAATATGTTAAGCTTCTGCCGAAGTTTGAAAATATGATTAATAACTCATTCTTGGATGAAG
AACTGCAAAGGAAATTTTCAGAGTTACTAAAAGAAAGACTTGATAGGCTTATTTTGGAATAG
Antitoxin
Download Length: 113 a.a. Molecular weight: 12442.43 Da Isoelectric Point: 4.0177
>AT38472 WP_207153958.1 NZ_AP024484:3093390-3093728 [Prevotella sp. WR041]
MKQANVYYKSQLAGVLTENDEGYEFCYLPAYLSSGSAKPVSLTLPLQEDIFKSSVLFPFFDGLIPEGWLLDIAIRDMDIS
ILDRMSLLLLCCKDCIGAVSIEPIQGKEVDNV
MKQANVYYKSQLAGVLTENDEGYEFCYLPAYLSSGSAKPVSLTLPLQEDIFKSSVLFPFFDGLIPEGWLLDIAIRDMDIS
ILDRMSLLLLCCKDCIGAVSIEPIQGKEVDNV
Download Length: 339 bp
>AT38472 NZ_AP024484:3093390-3093728 [Prevotella sp. WR041]
ATGAAACAAGCCAATGTTTATTATAAAAGTCAATTAGCCGGAGTATTGACAGAAAACGATGAAGGTTATGAATTTTGTTA
TCTTCCAGCCTATCTGTCGTCAGGAAGTGCTAAGCCTGTAAGTTTAACATTGCCATTGCAGGAAGATATATTTAAAAGTA
GCGTATTGTTTCCATTTTTCGATGGACTTATACCAGAAGGATGGCTGCTCGATATTGCTATTCGCGATATGGATATCAGT
ATTCTTGATCGTATGTCTCTACTATTGCTATGTTGCAAGGACTGTATCGGGGCGGTAAGTATTGAACCTATTCAAGGAAA
GGAGGTAGACAATGTGTAA
ATGAAACAAGCCAATGTTTATTATAAAAGTCAATTAGCCGGAGTATTGACAGAAAACGATGAAGGTTATGAATTTTGTTA
TCTTCCAGCCTATCTGTCGTCAGGAAGTGCTAAGCCTGTAAGTTTAACATTGCCATTGCAGGAAGATATATTTAAAAGTA
GCGTATTGTTTCCATTTTTCGATGGACTTATACCAGAAGGATGGCTGCTCGATATTGCTATTCGCGATATGGATATCAGT
ATTCTTGATCGTATGTCTCTACTATTGCTATGTTGCAAGGACTGTATCGGGGCGGTAAGTATTGAACCTATTCAAGGAAA
GGAGGTAGACAATGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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