Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2681628..2682252 Replicon chromosome
Accession NZ_AP024470
Organism Asaccharobacter celatus DSM 18785

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag ADLECEL_RS11300 Protein ID WP_117283568.1
Coordinates 2681628..2681909 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ADLECEL_RS11305 Protein ID WP_204019495.1
Coordinates 2681932..2682252 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADLECEL_RS11275 2677535..2678602 + 1068 WP_117283564.1 iron ABC transporter permease -
ADLECEL_RS11280 2678599..2679384 + 786 WP_117283565.1 ABC transporter ATP-binding protein -
ADLECEL_RS11285 2679406..2680575 + 1170 WP_117283566.1 ABC transporter substrate-binding protein -
ADLECEL_RS11290 2680716..2681174 - 459 WP_161959512.1 PIN domain-containing protein -
ADLECEL_RS11295 2681158..2681472 - 315 WP_147319425.1 hypothetical protein -
ADLECEL_RS11300 2681628..2681909 + 282 WP_117283568.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ADLECEL_RS11305 2681932..2682252 + 321 WP_204019495.1 HigA family addiction module antidote protein Antitoxin
ADLECEL_RS11310 2682509..2683366 - 858 WP_117283569.1 pyridoxamine kinase -
ADLECEL_RS11315 2683481..2684542 - 1062 WP_117283570.1 nucleoid-associated protein -
ADLECEL_RS11320 2684553..2685422 - 870 WP_117283571.1 twin-arginine translocation signal domain-containing protein -
ADLECEL_RS11325 2685449..2687053 - 1605 WP_117283572.1 DUF853 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(9-103)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10797.44 Da        Isoelectric Point: 8.5072

>T38470 WP_117283568.1 NZ_AP024470:2681628-2681909 [Asaccharobacter celatus DSM 18785]
MIKTFADSDTRALFETGQSKRLPADIVRRALRKLEYVDNAVLLTDLRLPPGNRLHALKGDRAGQFLISINDQWRICFRFK
PEGVYDVEMCDYH

Download         Length: 282 bp

>T38470 NZ_AP024470:2681628-2681909 [Asaccharobacter celatus DSM 18785]
ATGATAAAGACGTTCGCCGATTCCGACACACGGGCGCTGTTCGAAACGGGACAGAGCAAAAGGCTTCCTGCCGACATCGT
TCGCCGGGCGCTGCGAAAGCTGGAGTACGTCGACAACGCGGTCTTGCTGACCGATCTTCGACTTCCGCCGGGCAACCGGC
TGCACGCCCTGAAGGGCGATCGCGCCGGCCAGTTCTTGATTTCCATCAACGACCAATGGCGCATTTGCTTCAGGTTCAAA
CCCGAAGGAGTCTACGATGTCGAGATGTGCGACTACCACTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12054.99 Da        Isoelectric Point: 4.5467

>AT38470 WP_204019495.1 NZ_AP024470:2681932-2682252 [Asaccharobacter celatus DSM 18785]
MNDDMILVSREPVHPGEFLREDYMPELGLTVATLAKRLGVSRQTVNDIVREKRGLSPEMCLRLGRLFGTTPQFWMNMQSK
VDIWDSLALHEDEVMAIEPIEIAAIA

Download         Length: 321 bp

>AT38470 NZ_AP024470:2681932-2682252 [Asaccharobacter celatus DSM 18785]
ATGAACGATGACATGATTTTGGTGTCGCGCGAGCCCGTGCACCCGGGCGAGTTTTTGCGCGAGGATTATATGCCGGAGCT
GGGACTGACGGTGGCGACGCTGGCGAAGCGGCTGGGCGTATCGCGGCAGACCGTCAACGACATCGTGCGCGAGAAGCGGG
GCCTGAGCCCGGAGATGTGCCTTCGCCTGGGGCGCCTGTTCGGCACAACGCCCCAGTTCTGGATGAACATGCAGTCGAAG
GTGGACATCTGGGACTCTCTGGCGCTGCACGAGGACGAGGTCATGGCCATCGAGCCCATCGAGATAGCCGCCATCGCCTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References