Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1024449..1025055 Replicon chromosome
Accession NZ_AP024469
Organism Geobacter sp. SVR

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GSVR_RS04815 Protein ID WP_173195985.1
Coordinates 1024732..1025055 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GSVR_RS04810 Protein ID WP_173195987.1
Coordinates 1024449..1024739 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSVR_RS04790 1021604..1021909 + 306 WP_173195995.1 hypothetical protein -
GSVR_RS04795 1021998..1022618 - 621 WP_173195993.1 hypothetical protein -
GSVR_RS04800 1023111..1023317 - 207 WP_173195991.1 AlpA family phage regulatory protein -
GSVR_RS04805 1023565..1024413 + 849 WP_173195989.1 winged helix-turn-helix domain-containing protein -
GSVR_RS04810 1024449..1024739 - 291 WP_173195987.1 helix-turn-helix domain-containing protein Antitoxin
GSVR_RS04815 1024732..1025055 - 324 WP_173195985.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GSVR_RS04820 1025115..1026440 - 1326 WP_173195983.1 site-specific integrase -
GSVR_RS04825 1026641..1028245 - 1605 WP_173195981.1 recombinase family protein -
GSVR_RS04830 1028242..1028427 - 186 WP_173195979.1 hypothetical protein -
GSVR_RS04835 1029347..1029622 - 276 WP_173195977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 999032..1049683 50651


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-88)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12150.18 Da        Isoelectric Point: 9.6573

>T38464 WP_173195985.1 NZ_AP024469:c1025055-1024732 [Geobacter sp. SVR]
MEFIETPVFTKLIATMLPDDDYRLLQDDIAKNPQLGDLIQGGGGIRKLRFALPGTGKRGGARLIYYWQTSRDKIYMLLAY
AKAKKENLEPEQVAILKSLVKELERHG

Download         Length: 324 bp

>T38464 NZ_AP024469:c1025055-1024732 [Geobacter sp. SVR]
ATGGAATTTATCGAGACCCCAGTATTCACAAAGCTGATAGCAACTATGTTGCCCGATGATGATTACCGCCTTCTCCAAGA
CGATATTGCTAAGAACCCGCAATTAGGCGACTTGATTCAAGGCGGCGGTGGGATTCGTAAGCTTCGCTTCGCGCTGCCCG
GCACGGGCAAGCGGGGCGGTGCCCGCCTCATTTACTATTGGCAGACATCCAGGGATAAAATTTACATGCTGCTGGCATAC
GCCAAGGCAAAGAAAGAGAATCTTGAGCCGGAGCAGGTAGCCATACTCAAGTCATTAGTGAAGGAGTTGGAACGTCATGG
ATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10642.41 Da        Isoelectric Point: 9.8934

>AT38464 WP_173195987.1 NZ_AP024469:c1024739-1024449 [Geobacter sp. SVR]
MDKELFDQLHKSMKEAVAIAKGEMMPSRVFTVESPDVKAVREKTGLSQAMFAAMIGVKVKTLQNWEQHRRSPTGAAAALL
TIFDREPETAMKALHG

Download         Length: 291 bp

>AT38464 NZ_AP024469:c1024739-1024449 [Geobacter sp. SVR]
ATGGATAAAGAATTATTTGACCAATTACACAAAAGTATGAAAGAAGCCGTTGCGATTGCCAAAGGCGAAATGATGCCATC
AAGAGTATTCACTGTCGAGTCACCTGACGTGAAGGCCGTGCGCGAAAAAACGGGGCTGTCACAAGCCATGTTCGCCGCAA
TGATTGGTGTGAAGGTAAAAACCTTGCAAAATTGGGAGCAGCACCGGCGTAGCCCTACCGGTGCGGCAGCTGCGCTTCTG
ACTATATTTGACCGTGAACCGGAAACTGCTATGAAGGCTCTGCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References