Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2824767..2825428 Replicon chromosome
Accession NZ_AP024463
Organism Arachnia rubra strain SK-1

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag SK1NUM_RS12895 Protein ID WP_223927598.1
Coordinates 2824767..2825117 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag SK1NUM_RS12900 Protein ID WP_212322765.1
Coordinates 2825123..2825428 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SK1NUM_RS12880 (SK1NUM_25740) 2820663..2821958 + 1296 WP_212322753.1 histidine kinase -
SK1NUM_RS12885 (SK1NUM_25750) 2822117..2822917 + 801 WP_212322757.1 response regulator transcription factor -
SK1NUM_RS12890 (SK1NUM_25760) 2822985..2824220 - 1236 WP_212322759.1 beta-glucanase -
SK1NUM_RS12895 (SK1NUM_25780) 2824767..2825117 + 351 WP_223927598.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SK1NUM_RS12900 (SK1NUM_25790) 2825123..2825428 + 306 WP_212322765.1 helix-turn-helix transcriptional regulator Antitoxin
SK1NUM_RS12905 (SK1NUM_25810) 2826202..2826441 + 240 WP_212322767.1 antitoxin VbhA family protein -
SK1NUM_RS12915 2827044..2827964 - 921 WP_263407078.1 IS3 family transposase -
SK1NUM_RS12925 (SK1NUM_25840) 2828142..2828768 - 627 WP_212322772.1 winged helix-turn-helix domain-containing protein -
SK1NUM_RS12930 (SK1NUM_25850) 2829340..2830095 + 756 WP_212321357.1 transposase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2805142..2827871 22729


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(8-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-88)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13249.13 Da        Isoelectric Point: 6.4808

>T38457 WP_223927598.1 NZ_AP024463:2824767-2825117 [Arachnia rubra]
VDIELIADWLASLDDDSREQVVAAIELLEDRGPQLGRPIVDTVTSSRHRNMKELRPGSSGRSELRILFAFDPKRAAIMLI
AGNKAGNWVRWYKKNIPLADDLFDDHLRALRKVREE

Download         Length: 351 bp

>T38457 NZ_AP024463:2824767-2825117 [Arachnia rubra]
GTGGACATCGAGCTGATCGCAGACTGGCTCGCTTCACTGGACGATGACTCGCGCGAGCAAGTTGTTGCTGCTATCGAGTT
GCTAGAGGACCGTGGCCCGCAGCTTGGACGGCCCATCGTCGACACGGTGACATCGTCGCGGCACCGCAACATGAAGGAAC
TCCGGCCGGGATCGTCCGGGCGCTCCGAGTTGCGGATCCTGTTCGCCTTCGATCCCAAGCGAGCAGCGATCATGCTGATC
GCCGGTAACAAGGCGGGCAACTGGGTTCGTTGGTACAAGAAGAATATCCCGCTAGCCGATGACCTGTTCGATGACCACCT
ACGCGCATTGAGAAAGGTGAGAGAGGAGTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11379.01 Da        Isoelectric Point: 8.5624

>AT38457 WP_212322765.1 NZ_AP024463:2825123-2825428 [Arachnia rubra]
MAMTLKDFLAENPVDRERVEAHKERMLTEVRAYHLRELREQAGLTQAQLAERIGVGQRQVSKIEHGHLDNAKVGTIRNYL
KAVGGSLALEYVVGDQRVQVA

Download         Length: 306 bp

>AT38457 NZ_AP024463:2825123-2825428 [Arachnia rubra]
ATGGCCATGACACTGAAAGACTTCCTTGCTGAGAATCCCGTGGACCGGGAGCGTGTCGAGGCACACAAGGAACGGATGCT
CACAGAGGTCCGCGCCTACCACCTCCGCGAGCTGCGGGAGCAGGCAGGCTTGACCCAGGCCCAACTGGCCGAGCGGATTG
GCGTTGGCCAGCGTCAAGTCTCCAAAATCGAGCACGGCCACTTGGACAACGCGAAGGTCGGCACGATCCGCAACTACCTC
AAAGCCGTCGGCGGCAGTTTGGCCCTTGAATATGTGGTAGGAGACCAACGCGTGCAAGTCGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References