Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2981011..2981601 Replicon chromosome
Accession NZ_AP024452
Organism Luteitalea sp. TBR-22

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag TBR22_RS12215 Protein ID WP_239493267.1
Coordinates 2981323..2981601 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag TBR22_RS12210 Protein ID WP_239493266.1
Coordinates 2981011..2981313 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBR22_RS12180 (TBR22_24300) 2976475..2977272 + 798 WP_239493260.1 DUF2490 domain-containing protein -
TBR22_RS12185 (TBR22_24310) 2977326..2977814 + 489 WP_239493261.1 hypothetical protein -
TBR22_RS12190 (TBR22_24320) 2977915..2978211 + 297 WP_239493262.1 hypothetical protein -
TBR22_RS12195 (TBR22_24330) 2978236..2978694 + 459 WP_239493263.1 hypothetical protein -
TBR22_RS12200 (TBR22_24340) 2978825..2979232 - 408 WP_239493264.1 hypothetical protein -
TBR22_RS12205 (TBR22_24350) 2979256..2980701 - 1446 WP_239493265.1 sulfatase-like hydrolase/transferase -
TBR22_RS12210 (TBR22_24360) 2981011..2981313 - 303 WP_239493266.1 HigA family addiction module antitoxin Antitoxin
TBR22_RS12215 (TBR22_24370) 2981323..2981601 - 279 WP_239493267.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TBR22_RS12220 (TBR22_24380) 2981725..2981943 + 219 WP_239493268.1 hypothetical protein -
TBR22_RS12225 (TBR22_24390) 2982017..2983105 - 1089 WP_239493269.1 VWA domain-containing protein -
TBR22_RS12230 (TBR22_24400) 2983206..2983646 - 441 WP_239493270.1 hypothetical protein -
TBR22_RS12235 (TBR22_24410) 2983850..2985943 + 2094 WP_255665369.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-86)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10935.45 Da        Isoelectric Point: 9.0757

>T38451 WP_239493267.1 NZ_AP024452:c2981601-2981323 [Luteitalea sp. TBR-22]
VIRSFRDKDVELLFSDVPVRRFRAIERPARRKLLYLHRARTLEDLKVPPGNHLEALKGDHRGQHSIRINDQWRVCLTWTD
GDAHDVEIVDYH

Download         Length: 279 bp

>T38451 NZ_AP024452:c2981601-2981323 [Luteitalea sp. TBR-22]
GTGATTCGTTCCTTCCGGGACAAGGACGTGGAACTGCTGTTCAGCGACGTCCCGGTGAGGCGCTTCAGGGCCATCGAGCG
ACCTGCGCGGCGAAAGTTGTTGTACCTGCACCGCGCCCGCACCCTTGAAGACCTGAAGGTGCCGCCGGGGAACCATCTGG
AGGCCCTCAAGGGAGACCACCGGGGGCAGCACAGCATCCGGATCAACGATCAGTGGCGCGTGTGCCTCACGTGGACGGAC
GGCGATGCACACGACGTCGAGATCGTGGATTACCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11046.01 Da        Isoelectric Point: 9.9929

>AT38451 WP_239493266.1 NZ_AP024452:c2981313-2981011 [Luteitalea sp. TBR-22]
MKTTKMLEPIPPGEILMEEFMRPLGISINALARDLAVPPNRISGIINGTRAITADTALRLGKYFGVSPELWLDLQSDFEL
RVARQTVWPIVAASVKTRVA

Download         Length: 303 bp

>AT38451 NZ_AP024452:c2981313-2981011 [Luteitalea sp. TBR-22]
ATGAAGACCACCAAGATGCTTGAACCGATTCCGCCGGGCGAGATTCTGATGGAAGAGTTCATGCGGCCGCTGGGCATCAG
CATCAATGCGCTTGCCCGAGACCTGGCGGTACCGCCCAACCGCATCAGCGGCATCATCAACGGCACGCGGGCGATCACGG
CGGACACGGCGCTCCGGCTCGGCAAGTACTTCGGCGTGTCTCCGGAGCTCTGGCTCGACCTGCAGTCGGACTTCGAGCTG
CGCGTCGCGCGTCAGACCGTTTGGCCCATCGTGGCGGCGTCCGTGAAGACCAGGGTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References