Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 1944084..1944703 Replicon chromosome
Accession NZ_AP024452
Organism Luteitalea sp. TBR-22

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag TBR22_RS07905 Protein ID WP_239492426.1
Coordinates 1944084..1944401 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag TBR22_RS07910 Protein ID WP_239492427.1
Coordinates 1944398..1944703 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBR22_RS07885 (TBR22_15810) 1940079..1940414 + 336 WP_239492423.1 hypothetical protein -
TBR22_RS07890 (TBR22_15820) 1940505..1942148 + 1644 WP_239492424.1 aminotransferase class V-fold PLP-dependent enzyme -
TBR22_RS07895 (TBR22_15830) 1942195..1942701 + 507 WP_239492425.1 DUF4440 domain-containing protein -
TBR22_RS07900 (TBR22_15840) 1942915..1943862 + 948 WP_239493481.1 integron integrase -
TBR22_RS07905 (TBR22_15850) 1944084..1944401 + 318 WP_239492426.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TBR22_RS07910 (TBR22_15860) 1944398..1944703 + 306 WP_239492427.1 NadS family protein Antitoxin
TBR22_RS07915 (TBR22_15870) 1944907..1945287 + 381 WP_239492428.1 hypothetical protein -
TBR22_RS07920 (TBR22_15880) 1945403..1945675 + 273 WP_239492429.1 DUF4258 domain-containing protein -
TBR22_RS07925 (TBR22_15890) 1945672..1945941 + 270 WP_239492430.1 DUF2283 domain-containing protein -
TBR22_RS07930 (TBR22_A16010) 1946711..1946932 + 222 WP_239492431.1 addiction module protein -
TBR22_RS07935 (TBR22_15920) 1947746..1948917 + 1172 WP_239492432.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1942915..1951616 8701


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-72)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11832.72 Da        Isoelectric Point: 10.4861

>T38449 WP_239492426.1 NZ_AP024452:1944084-1944401 [Luteitalea sp. TBR-22]
MRFVETPIFTKVIGGLLDDEEYRSLQSSLMLRPDQGPIVRGSGGVRKVRWGRAGAGKRGSLRVLYYWAPRPSVVYMLYAY
AKNEQGDLTPAQVRALAALVREEFK

Download         Length: 318 bp

>T38449 NZ_AP024452:1944084-1944401 [Luteitalea sp. TBR-22]
ATGCGGTTCGTCGAGACGCCGATCTTCACCAAGGTCATCGGCGGACTGCTCGACGATGAGGAATACCGGTCGTTGCAATC
CTCCCTGATGCTGCGGCCCGACCAAGGGCCGATCGTGAGGGGCTCGGGAGGCGTGCGTAAAGTGCGCTGGGGTCGAGCCG
GTGCCGGGAAGCGCGGCAGCCTACGCGTGCTGTACTACTGGGCGCCCCGCCCATCGGTGGTCTACATGTTGTACGCCTAC
GCGAAGAACGAGCAGGGCGATCTCACGCCGGCGCAGGTGCGCGCGCTTGCCGCCCTCGTTCGAGAGGAGTTCAAGTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10929.78 Da        Isoelectric Point: 12.1788

>AT38449 WP_239492427.1 NZ_AP024452:1944398-1944703 [Luteitalea sp. TBR-22]
VKEAAFQELLGSVRQAGRIRRGTLKPARTTVFRPADIKAVRAKLGTSQPEFAVMIGVSVATLRNWEQGRRIPEGPALALL
RVAAKHPDIVIDALHGRRGAA

Download         Length: 306 bp

>AT38449 NZ_AP024452:1944398-1944703 [Luteitalea sp. TBR-22]
GTGAAAGAGGCGGCATTCCAGGAACTTCTAGGCAGCGTTCGCCAGGCGGGACGGATTCGGCGAGGCACGCTGAAGCCTGC
CCGGACGACGGTGTTCCGCCCCGCAGACATCAAGGCGGTCCGGGCCAAACTCGGCACATCGCAGCCGGAGTTCGCGGTCA
TGATCGGTGTGAGCGTCGCCACGCTCCGGAACTGGGAGCAGGGGCGGCGCATACCCGAGGGCCCGGCGCTTGCCCTGCTC
CGAGTGGCGGCCAAGCATCCCGACATCGTCATCGATGCGTTGCACGGCAGGCGCGGGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References